Epigenetics & Nuclear Signaling Antibodies 2

Anti-ABT1 Antibody (CAB5898)

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SKU:
CAB5898
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:Anti-ABT1 Antibody
Antibody SKU:CAB5898
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-272 of human ABT1 (NP_037507.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:HepG2, MCF7, HeLa, Jurkat, Mouse liver, Mouse heart, Rat liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-272 of human ABT1 (NP_037507.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MEAE ESEK AATE QEPL EGTE QTLD AEEE QEES EEAA CGSK KRVV PGIV YLGH IPPR FRPL HVRN LLSA YGEV GRVF FQAE DRFV RRKK KAAA AAGG KKRS YTKD YTEG WVEF RDKR IAKR VAAS LHNT PMGA RRRS PFRY DLWN LKYL HRFT WSHL SEHL AFER QVRR QRLR AEVA QAKR ETDF YLQS VERG QRFL AADG DPAR PDGS WTFA QRPT EQEL RARK AARP GGRE RARL ATAQ DKAR SNKG LLAR IFGA PPPS ESME GPSL VRDS
Gene ID:29777
Uniprot:Q9ULW3
Cellular Location:Nucleus, nucleolus
Calculated MW:31kDa
Observed MW:31kDa/36kDa
Synonyms:ABT1, hABT1, Esf2
Background:Basal transcription of genes by RNA polymerase II requires the interaction of TATA-binding protein (TBP) with the core region of class II promoters. Studies in mouse suggest that the protein encoded by this gene likely activates basal transcription from class II promoters by interaction with TBP and the class II promoter DNA.
UniProt Protein Function:ABT1: Could be a novel TATA-binding protein (TBP) which can function as a basal transcription activator. Can act as a regulator of basal transcription for class II genes. Belongs to the ESF2/ABP1 family.
UniProt Protein Details:

Protein type:Transcription factor; RNA-binding; Nucleolus

Chromosomal Location of Human Ortholog: 6p22.2

Cellular Component: transcription factor complex; nucleolus; nucleus

Molecular Function:protein binding; DNA binding; transcription coactivator activity; nucleotide binding

Biological Process: transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; spinal cord motor neuron differentiation

NCBI Summary:Basal transcription of genes by RNA polymerase II requires the interaction of TATA-binding protein (TBP) with the core region of class II promoters. Studies in mouse suggest that the protein encoded by this gene likely activates basal transcription from class II promoters by interaction with TBP and the class II promoter DNA. [provided by RefSeq, Jul 2008]
UniProt Code:Q9ULW3
NCBI GenInfo Identifier:74753396
NCBI Gene ID:29777
NCBI Accession:Q9ULW3.1
UniProt Related Accession:Q9ULW3
Molecular Weight:272
NCBI Full Name:Activator of basal transcription 1
NCBI Synonym Full Names:activator of basal transcription 1
NCBI Official Symbol:ABT1  
NCBI Official Synonym Symbols:hABT1  
NCBI Protein Information:activator of basal transcription 1; basal transcriptional activator; TATA-binding protein-binding protein
UniProt Protein Name:Activator of basal transcription 1
UniProt Synonym Protein Names:Basal transcriptional activator
Protein Family:Activator of basal transcription
UniProt Gene Name:ABT1  
UniProt Entry Name:ABT1_HUMAN
Anti-ABT1 Antibody (CAB5898)Western blot analysis of extracts of various cell lines, using ABT1 antibody (CAB5898) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 40s.
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