Antibody Name:	Anti-ABCD2 Antibody
Antibody SKU:	CAB16033
Antibody Size:	20uL, 50uL, 100uL
Application:	WB IF
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 420-500 of human ABCD2 (NP_005155.1).

Application:	WB IF
Recommended Dilution:	WB 1:500 - 1:2000 IF 1:50 - 1:100
Reactivity:	Human, Mouse, Rat
Positive Samples:

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 420-500 of human ABCD2 (NP_005155.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	TARV YNMF WVFD EVKR GIYK RTAV IQES ESHS KNGA KVEL PLSD TLAI KGKV IDVD HGII CENV PIIT PAGE VVAS RLNF K
Gene ID:	225
Uniprot:	Q9UBJ2
Cellular Location:	Multi-pass membrane protein, Peroxisome membrane
Calculated MW:	83kDa
Observed MW:	Refer to figures

Synonyms:

ABCD2, ABC39, ALDL1, ALDR, ALDRP, hALDR

Background:

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. The function of this peroxisomal membrane protein is unknown; however this protein is speculated to function as a dimerization partner of ABCD1 and/or other peroxisomal ABC transporters. Mutations in this gene have been observed in patients with adrenoleukodystrophy, a severe demyelinating disease. This gene has been identified as a candidate for a modifier gene, accounting for the extreme variation among adrenoleukodystrophy phenotypes. This gene is also a candidate for a complement group of Zellweger syndrome, a genetically heterogeneous disorder of peroxisomal biogenesis.

UniProt Protein Function:	ABCD2: Probable transporter. Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.
UniProt Protein Details:	Protein type:Membrane protein, integral; Membrane protein, multi-pass; Transporter, ABC family; Transporter Chromosomal Location of Human Ortholog: 12q12 Cellular Component: cytosol; intracellular membrane-bound organelle; peroxisomal membrane; peroxisome Molecular Function:long-chain fatty acid transporter activity; protein binding; protein homodimerization activity Biological Process: fatty acid beta-oxidation; positive regulation of fatty acid beta-oxidation; transmembrane transport; very-long-chain fatty acid catabolic process; very-long-chain fatty acid metabolic process
NCBI Summary:	The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. The function of this peroxisomal membrane protein is unknown; however this protein is speculated to function as a dimerization partner of ABCD1 and/or other peroxisomal ABC transporters. Mutations in this gene have been observed in patients with adrenoleukodystrophy, a severe demyelinating disease. This gene has been identified as a candidate for a modifier gene, accounting for the extreme variation among adrenoleukodystrophy phenotypes. This gene is also a candidate for a complement group of Zellweger syndrome, a genetically heterogeneous disorder of peroxisomal biogenesis. [provided by RefSeq, Jul 2008]
UniProt Code:	Q9UBJ2
NCBI GenInfo Identifier:	12643305
NCBI Gene ID:	225
NCBI Accession:	Q9UBJ2.1
UniProt Secondary Accession:	Q9UBJ2,Q13210, Q2M3H9, B2RAM3,
UniProt Related Accession:	Q9UBJ2
Molecular Weight:	83,233 Da
NCBI Full Name:	ATP-binding cassette sub-family D member 2
NCBI Synonym Full Names:	ATP binding cassette subfamily D member 2
NCBI Official Symbol:	ABCD2
NCBI Official Synonym Symbols:	ALDR; ABC39; ALDL1; ALDRP; hALDR
NCBI Protein Information:	ATP-binding cassette sub-family D member 2
UniProt Protein Name:	ATP-binding cassette sub-family D member 2
UniProt Synonym Protein Names:	Adrenoleukodystrophy-like 1; Adrenoleukodystrophy-related protein; hALDR
Protein Family:	ABC transporter D family
UniProt Gene Name:	ABCD2
UniProt Entry Name:	ABCD2_HUMAN

	Immunofluorescence analysis of L929 cells using ABCD2 Polyclonal Antibody (CAB16033) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
	Immunofluorescence analysis of U-2 OS cells using ABCD2 Polyclonal Antibody (CAB16033) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.