Signal Transduction Antibodies 2

Anti-ABCD2 Antibody (CAB16033)

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SKU:
CAB16033
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-ABCD2 Antibody
Antibody SKU:CAB16033
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 420-500 of human ABCD2 (NP_005155.1).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:100
Reactivity:Human, Mouse, Rat
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 420-500 of human ABCD2 (NP_005155.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:TARV YNMF WVFD EVKR GIYK RTAV IQES ESHS KNGA KVEL PLSD TLAI KGKV IDVD HGII CENV PIIT PAGE VVAS RLNF K
Gene ID:225
Uniprot:Q9UBJ2
Cellular Location:Multi-pass membrane protein, Peroxisome membrane
Calculated MW:83kDa
Observed MW:Refer to figures
Synonyms:ABCD2, ABC39, ALDL1, ALDR, ALDRP, hALDR
Background:The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. The function of this peroxisomal membrane protein is unknown; however this protein is speculated to function as a dimerization partner of ABCD1 and/or other peroxisomal ABC transporters. Mutations in this gene have been observed in patients with adrenoleukodystrophy, a severe demyelinating disease. This gene has been identified as a candidate for a modifier gene, accounting for the extreme variation among adrenoleukodystrophy phenotypes. This gene is also a candidate for a complement group of Zellweger syndrome, a genetically heterogeneous disorder of peroxisomal biogenesis.
UniProt Protein Function:ABCD2: Probable transporter. Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.
UniProt Protein Details:

Protein type:Membrane protein, integral; Membrane protein, multi-pass; Transporter, ABC family; Transporter

Chromosomal Location of Human Ortholog: 12q12

Cellular Component: cytosol; intracellular membrane-bound organelle; peroxisomal membrane; peroxisome

Molecular Function:long-chain fatty acid transporter activity; protein binding; protein homodimerization activity

Biological Process: fatty acid beta-oxidation; positive regulation of fatty acid beta-oxidation; transmembrane transport; very-long-chain fatty acid catabolic process; very-long-chain fatty acid metabolic process

NCBI Summary:The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. The function of this peroxisomal membrane protein is unknown; however this protein is speculated to function as a dimerization partner of ABCD1 and/or other peroxisomal ABC transporters. Mutations in this gene have been observed in patients with adrenoleukodystrophy, a severe demyelinating disease. This gene has been identified as a candidate for a modifier gene, accounting for the extreme variation among adrenoleukodystrophy phenotypes. This gene is also a candidate for a complement group of Zellweger syndrome, a genetically heterogeneous disorder of peroxisomal biogenesis. [provided by RefSeq, Jul 2008]
UniProt Code:Q9UBJ2
NCBI GenInfo Identifier:12643305
NCBI Gene ID:225
NCBI Accession:Q9UBJ2.1
UniProt Secondary Accession:Q9UBJ2,Q13210, Q2M3H9, B2RAM3,
UniProt Related Accession:Q9UBJ2
Molecular Weight:83,233 Da
NCBI Full Name:ATP-binding cassette sub-family D member 2
NCBI Synonym Full Names:ATP binding cassette subfamily D member 2
NCBI Official Symbol:ABCD2  
NCBI Official Synonym Symbols:ALDR; ABC39; ALDL1; ALDRP; hALDR  
NCBI Protein Information:ATP-binding cassette sub-family D member 2
UniProt Protein Name:ATP-binding cassette sub-family D member 2
UniProt Synonym Protein Names:Adrenoleukodystrophy-like 1; Adrenoleukodystrophy-related protein; hALDR
Protein Family:ABC transporter D family
UniProt Gene Name:ABCD2  
UniProt Entry Name:ABCD2_HUMAN
Anti-ABCD2 Antibody (CAB16033)Immunofluorescence analysis of L929 cells using ABCD2 Polyclonal Antibody (CAB16033) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
Anti-ABCD2 Antibody (CAB16033)Immunofluorescence analysis of U-2 OS cells using ABCD2 Polyclonal Antibody (CAB16033) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
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