Anti-A-RAF Antibody (CAB8687)

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SKU:
CAB8687
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
A-RAF
Synonyms:
ARAF1
Synonyms:
PKS2
Synonyms:
RAFA1
Research Area:
Cell Biology

Description

Product Name:A-RAF Rabbit mAb
Product Code:CAB8687
Size:20uL, 50uL, 100uL
Synonyms:A-RAF, ARAF1, PKS2, RAFA1
Applications:WB, IHC
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human A-RAF
Applications:WB, IHC
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human
Positive Samples:HeLa, MCF7
Immunogen:A synthesized peptide derived from human A-RAF
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:369
Uniprot:P10398
Calculated MW:68kDa
Observed MW:68KDa
UniProt Protein Function:ARAF: a tyrosine kinase-like kinase of the RAF family. Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May play a role in the postsynaptic responses of hippocampal neuron. Frequently mutated in thyroid cancers, skin melanomas and at lower frequency in a wide range of human cancers. An activating mutation, mimicking phosphorylation of the activation loop, is seen in 60% of malignant melanoma samples. Raf mutations are generally exclusive to Ras activating mutations. Activating mutations are also seen in ~10% of colorectal cancers, in lung cancers and gliomas, and at a lower rate in several other tumors. Inactivating mutations are also seen and may result in activation of c-Raf and Erk. Mutations in B-Raf, MEK1 and MEK2 also associated with cardiofaciocutaneous syndrome, displaying morphological, cardiac and mental defects. Approved Inhibitor: Nexavar/Sorafenib.
UniProt Protein Details:

Protein type:EC 2.7.11.1; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Protein kinase, TKL; TKL group; RAF family

Chromosomal Location of Human Ortholog: Xp11.4-p11.2

Cellular Component: cytosol

Molecular Function:protein binding; protein kinase activity; protein serine/threonine kinase activity

Biological Process: MAPKKK cascade; negative regulation of apoptosis; positive regulation of peptidyl-serine phosphorylation; protein modification process; regulation of proteasomal ubiquitin-dependent protein catabolic process; regulation of TOR signaling pathway

NCBI Summary:This proto-oncogene belongs to the RAF subfamily of the Ser/Thr protein kinase family, and maybe involved in cell growth and development. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2012]
UniProt Code:P10398
NCBI GenInfo Identifier:1730068
NCBI Gene ID:369
NCBI Accession:P10398.2
UniProt Secondary Accession:P10398,P07557, Q5H9B2, Q5H9B3,
UniProt Related Accession:P10398
Molecular Weight:20,904 Da
NCBI Full Name:Serine/threonine-protein kinase A-Raf
NCBI Synonym Full Names:A-Raf proto-oncogene, serine/threonine kinase
NCBI Official Symbol:ARAF  
NCBI Official Synonym Symbols:PKS2; A-RAF; ARAF1; RAFA1  
NCBI Protein Information:serine/threonine-protein kinase A-Raf
UniProt Protein Name:Serine/threonine-protein kinase A-Raf
UniProt Synonym Protein Names:Proto-oncogene A-Raf; Proto-oncogene A-Raf-1; Proto-oncogene Pks
Protein Family:ABC transporter L-arabinose-binding periplasmic protein
UniProt Gene Name:ARAF  
UniProt Entry Name:ARAF_HUMAN
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