Anti-5T4 Antibody (CAB19541)
- SKU:
- CAB19541
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- 5T4
- Synonyms:
- 5T4AG
- Synonyms:
- M6P1
- Synonyms:
- WAIF1
- Research Area:
- Cell Biology
Description
| Product Name: | 5T4 Rabbit mAb |
| Product Code: | CAB19541 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | 5T4, 5T4AG, M6P1, WAIF1 |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human 5T4 |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | A-549, MCF7 |
| Immunogen: | A synthesized peptide derived from human 5T4 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 7162 |
| Uniprot: | Q13641 |
| Calculated MW: | 72kDa |
| Observed MW: | 75KDa |
| UniProt Protein Function: | Subcellular location: Membrane; Single-pass type I membrane protein |
| UniProt Protein Details: | Potential. Tissue specificity: Expressed by all types of trophoblasts as early as 9 weeks of development. Specific for trophoblastic cells except for amniotic epithelium. In adult tissues, the expression is limited to a few epithelial cell types but is found on a variety of carcinoma. Miscellaneous: Antigen 5T4 is overexpressed by a wide spectrum of cancers, including colorectal, ovarian and gastric, but with a limited normal tissue expression. Could be used for tumor immunotherapy. Sequence similarities: Contains 6 LRR (leucine-rich) repeats.Contains 1 LRRCT domain.Contains 1 LRRNT domain. |
| NCBI Summary: | This gene encodes a leucine-rich transmembrane glycoprotein that may be involved in cell adhesion. The encoded protein is an oncofetal antigen that is specific to trophoblast cells. In adults this protein is highly expressed in many tumor cells and is associated with poor clinical outcome in numerous cancers. Alternate splicing in the 5' UTR results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2009] |
| UniProt Code: | Q13641 |
| NCBI GenInfo Identifier: | 262205665 |
| NCBI Gene ID: | 7162 |
| NCBI Accession: | NP_001159864.1 |
| UniProt Related Accession: | Q13641 |
| Molecular Weight: | 46,032 Da |
| NCBI Full Name: | trophoblast glycoprotein |
| NCBI Synonym Full Names: | trophoblast glycoprotein |
| NCBI Official Symbol: | TPBG |
| NCBI Official Synonym Symbols: | 5T4; M6P1; 5T4AG |
| NCBI Protein Information: | trophoblast glycoprotein; 5T4 oncofetal antigen; 5T4 oncotrophoblast glycoprotein; 5T4 oncofetal trophoblast glycoprotein |
| UniProt Protein Name: | Trophoblast glycoprotein |
| UniProt Synonym Protein Names: | 5T4 oncofetal antigen; 5T4 oncofetal trophoblast glycoprotein; 5T4 oncotrophoblast glycoprotein; M6P1 |
| Protein Family: | Trophoblast glycoprotein |
| UniProt Gene Name: | TPBG |
| UniProt Entry Name: | TPBG_HUMAN |
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