AMPKα2 Polyclonal Antibody
- SKU:
- CAB0791
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IF
Description
| Product Name: | AMPKα2 Polyclonal Antibody |
| Product Code: | CAB0791 |
| Reactivity: | Human, Rat |
| Applications: | Western blotting, Immunofluorescence |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human, Rat |
| Tested Applications: | WB, IF/ICC, ELISA |
| Key Applications: | Western blotting, Immunofluorescence |
| Recommended Dilution: | WB 1:500-1:1000, IF/ICC 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Positive Samples: | K-562 |
| Cellular Location: | Cytoplasm, Nucleus |
| Customer Validation: | WB(Homo sapiens) |
The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 270-343 of human PRKAA2 (NP_006243.2). |
| Sequence: | QDLPS YLFPE DPSYD ANVID DEAVK EVCEK FECTE SEVMN SLYSG DPQDQ LAVAY HLIID NRRIM NQASE FYLA |
| Synonyms: | AMPK, AMPK2, PRKAA, AMPKa2 |
| Calculated MW: | 62kDa |
| Observed MW: | 62kDa |
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