AMACR/p504S Monoclonal Antibody
- SKU:
- CAB22407
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IHC
Description
| Product Name: | AMACR/p504S Monoclonal Antibody |
| Product Code: | CAB22407 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting, Immunohistochemistry |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC50876 |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, IHC-P, ELISA |
| Key Applications: | Western blotting, Immunohistochemistry |
| Recommended Dilution: | WB 1:500-1:1000, IHC-P 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | LNCaP cells, Mouse liver, Mouse kidney, Rat liver, Rat kidney |
| Cellular Location: | Cytoplasm, Mitochondrion, Peroxisome |
This gene encodes a racemase. The encoded enzyme interconverts pristanoyl-CoA and C27-bile acylCoAs between their (R)- and (S)-stereoisomers. The conversion to the (S)-stereoisomers is necessary for degradation of these substrates by peroxisomal beta-oxidation. Encoded proteins from this locus localize to both mitochondria and peroxisomes. Mutations in this gene may be associated with adult-onset sensorimotor neuropathy, pigmentary retinopathy, and adrenomyeloneuropathy due to defects in bile acid synthesis. Alternatively spliced transcript variants have been described. Read-through transcription also exists between this gene and the upstream neighboring C1QTNF3 (C1q and tumor necrosis factor related protein 3) gene.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-138 of human AMACR (NP_055139.4). |
| Sequence: | MALQG ISVVE LSGLA PGPFC AMVLA DFGAR VVRVD RPGSR YDVSR LGRGK RSLVL DLKQP RGAAV LRRLC KRSDV LLEPF RRGVM EKLQL GPEIL QRENP RLIYA RLSGF GQSGS FCRLA GHDIN YLALS GVLSK IGR |
| Synonyms: | RM, RACE, CBAS4, P504S, AMACRD |
| Calculated MW: | 42kDa |
| Observed MW: | 42kDa |
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