ALKBH5 Monoclonal Antibody
- SKU:
- CAB22137
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IHC
Description
| Product Name: | ALKBH5 Monoclonal Antibody |
| Product Code: | CAB22137 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting, Immunohistochemistry |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC55858 |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, IHC-P, ELISA |
| Key Applications: | Western blotting, Immunohistochemistry |
| Recommended Dilution: | WB 1:2000-1:10000, IHC-P 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | Jurkat, F9, PC-12 |
| Cellular Location: | cytosol, Golgi apparatus, nuclear speck, nucleoplasm, nucleus |
Enables mRNA N6-methyladenosine dioxygenase activity. Involved in RNA metabolic process; mRNA export from nucleus; and response to hypoxia. Located in Golgi apparatus; cytosol; and nuclear speck.ALKBH5, also named as ABH5 and OFOXD1, is a Dioxygenase that demethylates RNA by oxidative demethylation. It is a mammalian demethylase that oxidatively reverses m6A in mRNA in vitro and in vivo. ALKBH5 is required for spermatogenesis.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 66-394 of human ALKBH5 (NP_060228.3). |
| Sequence: | PERSD YEEQQ LQKEE EARKV KSGIR QMRLF SQDEC AKIEA RIDEV VSRAE KGLYN EHTVD RAPLR NKYFF GEGYT YGAQL QKRGP GQERL YPPGD VDEIP EWVHQ LVIQK LVEHR VIPEG FVNSA VINDY QPGGC IVSHV DPIHI FERPI VSVSF FSDSA LCFGC KFQFK PIRVS EPVLS LPVRR GSVTV LSGYA ADEIT HCIRP QDIKE RRAVI ILRKT RLDAP RLETK SLSSS VLPPS YASDR LSGNN RDPAL KPKRS HRKAD PDAAH RPRIL EMDKE ENRRS VLLPT HRRRG SFSSE NYWRK SYESS EDCSE AAGSP ARKVK MRRH |
| Synonyms: | ABH5, OFOXD, OFOXD1 |
| Calculated MW: | 44kDa |
| Observed MW: | 44-48kDa |
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