AF/LE Purified Mouse/Human CD44 Monoclonal Antibody [IM7](AGEL1274)

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SKU:
AGEL1274
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Applications:
FC

Description

Antibody Name:AF/LE Purified Mouse/Human CD44 Monoclonal Antibody
Antibody Code:AGEL1274
Size:500µg
Clone:IM7
Synonyms:CD44 antigen,CD44,CDw44,Epican,Phagocytic glycoprotein 1,PGP-1,Phagocytic glycoprotein I,PGP-I,CD44,LHR, MDU2, MDU3, MIC4
Host Species:Rat
Species Reactivity:Human, Mouse
Applications:Neut, FC, IHC, IP
Concentration:1mg/mL
Isotype:IgG2a,k
Conjugation:Azide Free/Low endotoxin
Applications:Neut, FC, IHC, IP
Recommended Dilution:Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 10e6 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Storage Buffer:PBS, PH7.2
Storage:Store at 2-8°C. Do not freeze.
Gene ID:12505,960
Uniprot:P15379, P16070
Background:CD44 is a 80-95 kD glycoprotein also known as Hermes, Pgp1, H-CAM, or HUTCH. It is expressed on all leukocytes, endothelial cells, hepatocytes, and mesenchymal cells. As B and T cells become activated or progress to the memory stage, CD44 expression increases from low or mid levels to high levels. Thus, CD44 has been reported to be a valuable marker for memory cell subsets. High CD44 expression on Treg cells has been associated with potent suppressive function via high production of IL-10. CD44 is an adhesion molecule involved in leukocyte attachment to and rolling on endothelial cells, homing to peripheral lymphoid organs and to the sites of inflammation, and leukocyte aggregation.
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