AF/LE Purified Anti-Mouse CD54 Antibody [YN1/1.7.4]
![AF/LE Purified Anti-Mouse CD54 Antibody [YN1/1.7.4]](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/608x608/products/87495/91753/afle-purified-anti-mouse-cd54-antibody-yn11.7.4__96081__16712.1706549878.jpg?c=1 "AF/LE Purified Anti-Mouse CD54 Antibody [YN1/1.7.4]")
- SKU:
- AGEL2154
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Applications:
- FCM
- Reactivity:
- Mouse
- Host Species:
- Rat
- Isotype:
- Rat IgG2b, κ
- Clone:
- YN1/1.7.4
- Conjugation:
- None (Low endotoxin)
![AF/LE Purified Anti-Mouse CD54 Antibody [YN1/1.7.4]](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/1280x1280/products/87495/91753/afle-purified-anti-mouse-cd54-antibody-yn11.7.4__96081__16712.1706549878.jpg?c=1&imbypass=on "AF/LE Purified Anti-Mouse CD54 Antibody [YN1/1.7.4]")
Description
| Product Name: | AF/LE Purified Anti-Mouse CD54 Antibody [YN1/1.7.4] |
| Product Code: | AGEL2154 |
| Clone No: | YN1/1.7.4 |
| Synonyms: | Intercellular adhesion molecule 1,Icam1,MALA-2,MyD10,CD54,Icam-1 |
| Reactivity: | Mouse |
| Host Species: | Rat |
| Applications: | FCM |
| Isotype: | Rat IgG2b, κ |
| Isotype Control: | Low Endotoxin Purified Rat IgG2b, κ Isotype Control [LTF-2] (AGEL2676) |
| Conjugation: | None (Purified antibody-Azide Free/Low endotoxin) |
| Form: | Liquid |
| Recommended Use: | Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. |
| Storage Buffer: | 0.2 μm filtered in PBS, pH 7.2. Azide Free (AF)/Low Endotoxin (LE): Contains no stabilizers or stabilizers. Endotoxin level is < 2 EU/mg as Determined by LAL gel clotting assay. |
| Swissprot: | P13597 |
| Stability & Storage: | Keep as concentrated solution. Store at 2-8°C. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase. |
| Shipping: | Biological ice pack at 4°C |
CD54 is a 90 kD immunoglobulin superfamily member also known as ICAM-1 and Ly-47. It is expressed on activated endothelial cells, high endothelial venules (HEV), T and B cells, monocytes/ macrophages, granulocytes, and dendritic cells. CD54 is an important intracellular adhesion molecule that participates in T cell-T cell, T cell-B cell, and T cell-target cell interactions via binding of LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18). CD54 has also been shown to be involved in lymphocyte trafficking, making it an important molecule in many immune reactions and inflammation. CD54 is also a receptor for rhinovirus. The YN1/1.7.4 antibody has been reported to block binding of mouse CD54 to LFA-1 and Mac-1, inhibit cell-cell adhesion, and function in antigen presentation to T cells and leukocyte migration to inflammatory tissues.
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