AF/LE Purified Anti-Mouse CD40 Antibody [FGK4.5/FGK45]
- SKU:
- AGEL2160
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Applications:
- FCM
- Reactivity:
- Mouse
- Host Species:
- Rat
- Isotype:
- Rat IgG2a, κ
- Clone:
- FGK4.5/FGK45
- Conjugation:
- None (Low endotoxin)
Description
Product Name: | AF/LE Purified Anti-Mouse CD40 Antibody [FGK4.5/FGK45] |
Product Code: | AGEL2160 |
Clone No: | FGK4.5/FGK45 |
Synonyms: | Tumor necrosis factor receptor superfamily member 5,Cd40,B-cell surface antigen CD40,Bp50,CD40L receptor,CD40,Tnfrsf5 |
Reactivity: | Mouse |
Host Species: | Rat |
Applications: | FCM |
Isotype: | Rat IgG2a, κ |
Isotype Control: | Low Endotoxin Purified Rat IgG2a, κ Isotype Control [2A3] (AGEL2652) |
Conjugation: | None (Purified antibody-Azide Free/Low endotoxin) |
Form: | Liquid |
Recommended Use: | Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. |
Storage Buffer: | 0.2 μm filtered in PBS, pH 7.2. Azide Free (AF)/Low Endotoxin (LE): Contains no stabilizers or stabilizers. Endotoxin level is < 2 EU/mg as Determined by LAL gel clotting assay. |
Swissprot: | P27512 |
Stability & Storage: | Keep as concentrated solution. Store at 2-8°C. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase. |
Shipping: | Biological ice pack at 4°C |
CD40 is a 48 kD type I transmembrane glycoprotein also known as Bp50. It is a member of the tumor necrosis factor receptor (TNFR) superfamily and is expressed on B cells, basal epithelial cells, macrophages, follicular dendritic cells, endothelial cells, and a subset of CD34+ hematopoietic progenitors. CD40 regulates B cell development/maturation, Ig isotype switching and, in combination with other signals such as IL-4, protects B cells from surface Ig-induced apoptosis and promotes proliferation. Interaction of CD40 with its ligand CD154 (gp39), which is expressed on activated T cells, is important in costimulation and immune regulation.