AF/LE Purified Anti-Mouse CD366/Tim-3 Antibody [RMT3-23]

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SKU:
AGEL2360
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FCM
Applications:
Block
Reactivity:
Mouse
Host Species:
Rat
Isotype:
Rat IgG2a, κ
Clone:
RMT3-23
Conjugation:
None (Low endotoxin)

Description

Product Name:AF/LE Purified Anti-Mouse CD366/Tim-3 Antibody [RMT3-23]
Product Code:AGEL2360
Clone No:RMT3-23
Synonyms:TIM3, TIMD3,HAVcr-2,TIMD-3
Reactivity:Mouse
Host Species:Rat
Applications:FCM, Block
Isotype:Rat IgG2a, κ
Isotype Control:Low Endotoxin Purified Rat IgG2a, κ Isotype Control [2A3] (AGEL2652)
Conjugation:None (Purified antibody-Azide Free/Low endotoxin)
Form:Liquid
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 2.0 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Storage Buffer:0.2 μm filtered in PBS, pH 7.2. Azide Free (AF)/Low Endotoxin (LE): Contains no stabilizers or stabilizers. Endotoxin level is < 2 EU/mg as Determined by LAL gel clotting assay.
Swissprot:Q8VIM0
Stability & Storage:Keep as concentrated solution. Store at 2-8°C. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Shipping:Biological ice pack at 4°C

CD366 (Tim-3) is a transmembrane protein also known as T cell immunoglobulin and mucin domain containing protein-3. Tim-3 is expressed at high levels on activated T cells (preferentially on Th1 cells, monocytes/macrophages, and dendritic cells). Tim-3 has also been shown to exist as a soluble protein. Cells expressing Tim-3 are present at high levels in the CNS of animals at the onset of experimental autoimmune encephalomyelitis (EAE), a disease mediated by lymphocytes secreting Th1-like cytokines. Tim-3 has been proposed to inhibit Th1-mediated immune responses and promote immunological tolerance.

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