Activin Receptor 2B/ACVR2B Recombinant Protein (RPES2019)
- SKU:
- RPES2019
- Product Type:
- Recombinant Protein
- Species:
- Human
Description
Activin Receptor 2B/ACVR2B Recombinant Protein
Activin proteins that belong to the transforming growth factor-beta (TGF-β) superfamily; exert their biological actions by binding to heteromeric receptor complexes of type I and type II serine/threonine kinase receptors. On ligand binding; type I and II receptors form a stable complex; resulting in phosphorylation of type I receptors by type II receptors with constitutive kinase activity; and subsequently initiates the activation of downstream molecules including the endogenous Smads. ActRIIB; also known as ActRIIB; is a type II receptor containing an extracellular domain (ECD); a transmembrane segment; and a cytoplasmic region that includes the kinase domain. ActRIIB is a receptor for activin A; activin B and inhibin A. Multiple ActRIIB isoforms can also be generated; which bind activin isoforms with different affinities.
| Product Name: | Activin Receptor 2B/ACVR2B Recombinant Protein (RPES2019) |
| Product Code: | RPES2019 |
| Size: | 10µg |
| Species: | Human |
| Expressed Host: | Human Cells |
| Synonyms: | Activin Receptor Type-2B, Activin Receptor Type IIB, ACTR-IIB, ACVR2B,Bone Morphogenetic Protein Receptor Type-2, BMP Type-2 Receptor, BMPR-3, Bone Morphogenetic Protein Receptor Type II, BMP Type II Receptor |
| Accession: | Q13705 |
| Sequence: | Ser19-Thr134 |
| Fusion tag: | C-Fc-6His |
| Activity: | Immobilized Human/Mouse/Rat Activin A(Cat: PKSH033807) at 5µg/ml(100 ?l/well) can bind Human ACVR2B-His. The ED50 of Human ACVR2B-His is 20.58 ng/ml . |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | Recombinant Human Activin Receptor Type 2B is produced by our Mammalian expression system and the target gene encoding Ser19-Thr134 is expressed with a Fc; 6His tag at the C-terminus. |
| Purity: | > 95 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 41.3 kDa |
| AP Mol Mass: | 60 kDa |
| Formulation: | Lyophilized from a 0.2 µm filtered solution of 20mM PB;150mM NaCl;pH7.4. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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