ACLY Monoclonal Antibody
- SKU:
- CAB22273
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IHC
Description
| Product Name: | ACLY Monoclonal Antibody |
| Product Code: | CAB22273 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting, Immunohistochemistry |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC56113 |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, IHC-P, ELISA |
| Key Applications: | Western blotting, Immunohistochemistry |
| Recommended Dilution: | WB 1:1000-1:5000, IHC-P 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | HeLa, HepG2, NIH/3T3, Mouse lung, Mouse testis, C6 |
| Cellular Location: | Cytoplasm, Cytosol |
ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440, 000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Multiple transcript variants encoding distinct isoforms have been identified for this gene.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 752-1101 of human ACLY (NP_001087.2). |
| Sequence: | FSSEV QFGHA GACAN QASET AVAKN QALKE AGVFV PRSFD ELGEI IQSVY EDLVA NGVIV PAQEV PPPTV PMDYS WAREL GLIRK PASFM TSICD ERGQE LIYAG MPITE VFKEE MGIGG VLGLL WFQKR LPKYS CQFIE MCLMV TADHG PAVSG AHNTI ICARA GKDLV SSLTS GLLTI GDRFG GALDA AAKMF SKAFD SGIIP MEFVN KMKKE GKLIM GIGHR VKSIN NPDMR VQILK DYVRQ HFPAT PLLDY ALEVE KITTS KKPNL ILNVD GLIGV AFVDM LRNCG SFTRE EADEY IDIGA LNGIF VLGRS MGFIG HYLDQ KRLKQ GLYRH PWDDI SYVLP EHMSM |
| Synonyms: | ACL, ATPCL, CLATP |
| Calculated MW: | 121kDa |
| Observed MW: | 125kDa |
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