ACKR2 Antibody (PACO00593)
- SKU:
- PACO00593
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | ACKR2 Antibody |
| Antibody SKU: | PACO00593 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000 |
| Species Reactivity: | Human |
| Immunogen: | synthesized peptide derived from the C-terminal region of human Chemokine Receptor D6. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | CCBP2; CCR10; CMKBR9; Chemokine-binding protein 2; C-C chemokine receptor D6; Chemokine receptor CCR-10; Chemokine receptor CCR-9; Chemokine-binding protein D6 |
| UniProt Protein Function: | CCBP2: Receptor for C-C type chemokines including SCYA2/MCP-1, SCY3/MIP-1-alpha, SCYA5/RANTES and SCYA7/MCP-3. Belongs to the G-protein coupled receptor 1 family.Protein type: Membrane protein, integral; Receptor, GPCR; GPCR, family 1; Membrane protein, multi-passChromosomal Location of Human Ortholog: 3p21.3Cellular Component: recycling endosome; integral to plasma membrane; early endosome; plasma membrane; actin filamentMolecular Function: C-C chemokine receptor activity; chemokine receptor activity; C-C chemokine binding; scavenger receptor activity; C-X-C chemokine receptor activityBiological Process: G-protein coupled receptor protein signaling pathway; receptor-mediated endocytosis; neutrophil activation; multicellular organismal development; immune response; chemotaxis; inflammatory response |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cells to the inflammation site. This gene is expressed in a range of tissues and hemopoietic cells. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members; however, its specific function remains unknown. This gene is mapped to chromosome 3p21.3, a region that includes a cluster of chemokine receptor genes. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O00590 |
| NCBI GenInfo Identifier: | 13929467 |
| NCBI Gene ID: | 1238 |
| NCBI Accession: | NP_001287.2 |
| UniProt Secondary Accession: | O00590 |
| UniProt Related Accession: | O00590 |
| Molecular Weight: | ~ 44kDa |
| NCBI Full Name: | atypical chemokine receptor 2 |
| NCBI Synonym Full Names: | atypical chemokine receptor 2 |
| NCBI Official Symbol: | ACKR2 |
| NCBI Official Synonym Symbols: | D6; hD6; CCR9; CCBP2; CCR10; CMKBR9 |
| NCBI Protein Information: | atypical chemokine receptor 2 |
| UniProt Protein Name: | Chemokine-binding protein 2 |
| UniProt Synonym Protein Names: | C-C chemokine receptor D6; Chemokine receptor CCR-10; Chemokine receptor CCR-9; Chemokine-binding protein D6 |
| Protein Family: | |
| UniProt Gene Name: | CCBP2 |
| UniProt Entry Name: | CCBP2_HUMAN |
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