ZRSR2 Antibody (PACO48590)
- SKU:
- PACO48590
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | ZRSR2 Antibody (PACO48590) |
| Antibody SKU: | PACO48590 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Recombinant Human U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 protein (191-372AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: K562 whole cell lysate, HEK293 whole cell lysate, Mouse heart tissue. All lanes: ZRSR2 antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 59 kDa. Observed band size: 59 kDa.. |
 | Immunofluorescent analysis of HepG2 cells using PACO48590 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
 | Immunohistochemistry of paraffin-embedded human testis tissue using PACO48590 at dilution of 1:100. |
| Background: | Pre-mRNA-binding protein required for splicing of both U2- and U12-type introns. Selectively interacts with the 3'-splice site of U2- and U12-type pre-mRNAs and promotes different steps in U2 and U12 intron splicing. Recruited to U12 pre-mRNAs in an ATP-dependent manner and is required for assembly of the prespliceosome, a precursor to other spliceosomal complexes. For U2-type introns, it is selectively and specifically required for the second step of splicing. |
| Synonyms: | U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 2) (Renal carcinoma antigen NY-REN-20) (U2(RNU2) small nuclear RNA auxiliary factor 1-like 2) (U2AF35-related protein) (URP), ZRSR2, U2AF1-RS2 U2AF1L2 U2AF1RS2 URP |
| UniProt Protein Function: | ZRSR2: Pre-mRNA-binding protein required for splicing of both U2- and U12-type introns. Selectively interacts with the 3'-splice site of U2- and U12-type pre-mRNAs and promotes different steps in U2 and U12 intron splicing. Recruited to U12 pre-mRNAs in an ATP- dependent manner and is required for assembly of the prespliceosome, a precursor to other spliceosomal complexes. For U2-type introns, it is selectively and specifically required for the second step of splicing.Protein type: RNA splicingChromosomal Location of Human Ortholog: Xp22.1Cellular Component: U12-dependent spliceosomeMolecular Function: pre-mRNA 3'-splice site binding; protein bindingBiological Process: nuclear mRNA splicing, via spliceosome; RNA splicing; spliceosome assembly |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes an essential splicing factor. The encoded protein associates with the U2 auxiliary factor heterodimer, which is required for the recognition of a functional 3' splice site in pre-mRNA splicing, and may play a role in network interactions during spliceosome assembly. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q15696 |
| NCBI GenInfo Identifier: | 2833266 |
| NCBI Gene ID: | 8233 |
| NCBI Accession: | Q15696.2 |
| UniProt Secondary Accession: | Q15696,Q14D69 |
| UniProt Related Accession: | Q15696 |
| Molecular Weight: | 58,045 Da |
| NCBI Full Name: | U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 |
| NCBI Synonym Full Names: | zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2 |
| NCBI Official Symbol: | ZRSR2 |
| NCBI Official Synonym Symbols: | URP; ZC3H22; U2AF1L2; U2AF1RS2; U2AF1-RS2 |
| NCBI Protein Information: | U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 |
| UniProt Protein Name: | U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 |
| UniProt Synonym Protein Names: | CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 2; Renal carcinoma antigen NY-REN-20; U2(RNU2) small nuclear RNA auxiliary factor 1-like 2; U2AF35-related protein; URP |
| Protein Family: | U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein |
| UniProt Gene Name: | ZRSR2 |
| UniProt Entry Name: | U2AFM_HUMAN |
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