Name: ZNF420 Antibody (PACO62727)
SKU: PACO62727
Availability: OutOfStock

Antibody Name:	ZNF420 Antibody (PACO62727)
Antibody SKU:	PACO62727
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, IHC
Recommended Dilutions:	ELISA:1:2000-1:10000, IHC:1:200-1:500
Species Reactivity:	Human
Immunogen:	Recombinant Human Zinc finger protein 420 protein (50-256AA)

Form:	Liquid
Storage Buffer:	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method:	>95%, Protein G purified
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

IHC image of PACO62727 diluted at 1:300 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Background:	May be involved in transcriptional regulation.
Synonyms:	Zinc finger protein 420, ZNF420

UniProt Protein Function:	ZNF420: May be involved in transcriptional regulation.Protein type: Transcription factor; C2H2-type zinc finger proteinChromosomal Location of Human Ortholog: 19q13.12Cellular Component: nucleusMolecular Function: protein binding; DNA binding; metal ion binding; transcription factor activityBiological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent
UniProt Protein Details:
NCBI Summary:	The protein encoded by this gene is a KRAB-type zinc finger protein that negatively-regulates p53-mediated apoptosis. Under stress conditions, the encoded protein is phosphorylated by ATM and dissociates from p53, which activates p53 and initiates apoptosis. [provided by RefSeq, Jul 2016]
UniProt Code:	Q8TAQ5
NCBI GenInfo Identifier:	22095393
NCBI Gene ID:	147923
NCBI Accession:	NP_653290
UniProt Secondary Accession:	Q8TAQ5
UniProt Related Accession:	Q8TAQ5
Molecular Weight:	80kDa
NCBI Full Name:	zinc finger protein 420 isoform b
NCBI Synonym Full Names:	zinc finger protein 420
NCBI Official Symbol:	ZNF420
NCBI Official Synonym Symbols:	APAK
NCBI Protein Information:	zinc finger protein 420
UniProt Protein Name:	Zinc finger protein 420
UniProt Synonym Protein Names:
Protein Family:	Zinc finger protein
UniProt Gene Name:	ZNF420
UniProt Entry Name:	ZN420_HUMAN