ZNF395 Antibody (PACO19749)
- SKU:
- PACO19749
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | ZNF395 Antibody (PACO19749) |
| Antibody SKU: | PACO19749 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Synthetic peptide of human ZNF395 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using PACO19749(ZNF395 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. As a member of the krueppel C2H2-type zinc-finger protein family, ZNF395 (Zinc finger protein 395), also known as PBF (Papillomavirus-binding factor) and HDBP2 (Huntington disease gene regulatory region-binding protein 2), is a 513 amino acid, protein that contains one C2H2-type zinc finger. ZNF395 binds to the 3-CCGG-5 sequence within the papillomavirus promoter adjacent to a RUNX1-binding motif. It has also been established that ZNF395 binds to a seven base pair region within the Huntington's disease (HD) gene promoter, an essential element for HD gene expression. ZNF395 is widely expressed and probably shuttles between the nucleus and cytoplasm. |
| Synonyms: | zinc finger protein 395 |
| UniProt Protein Function: | ZNF395: Plays a role in papillomavirus genes transcription.Protein type: Transcription factor; C2H2-type zinc finger proteinChromosomal Location of Human Ortholog: 8p21.1Cellular Component: cytoplasm; nucleusMolecular Function: DNA bindingBiological Process: regulation of transcription, DNA-dependent |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q9H8N7 |
| NCBI GenInfo Identifier: | 84028224 |
| NCBI Gene ID: | 55893 |
| NCBI Accession: | Q9H8N7.2 |
| UniProt Secondary Accession: | Q9H8N7,Q6F6H2, Q9BY72, Q9NPB2, Q9NS57, Q9NS58, Q9NS59 B3KUY7, D3DST4 |
| UniProt Related Accession: | Q9H8N7 |
| Molecular Weight: | 54,939 Da |
| NCBI Full Name: | Zinc finger protein 395 |
| NCBI Synonym Full Names: | zinc finger protein 395 |
| NCBI Official Symbol: | ZNF395 |
| NCBI Official Synonym Symbols: | PBF; PRF1; HDBP2; PRF-1; HDBP-2; HDRF-2; Si-1-8-14 |
| NCBI Protein Information: | zinc finger protein 395 |
| UniProt Protein Name: | Zinc finger protein 395 |
| UniProt Synonym Protein Names: | HD-regulating factor 2; HDRF-2; Huntington disease gene regulatory region-binding protein 2; HD gene regulatory region-binding protein 2; HDBP-2; Papillomavirus regulatory factor 1; PRF-1; Papillomavirus-binding factor |
| Protein Family: | Zinc finger protein |
| UniProt Gene Name: | ZNF395 |
| UniProt Entry Name: | ZN395_HUMAN |
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