ZNF365 Antibody (PACO46694)
- SKU:
- PACO46694
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | ZNF365 Antibody (PACO46694) |
| Antibody SKU: | PACO46694 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Protein ZNF365 protein (241-401AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human brain tissue using PACO46694 at dilution of 1:100. |
 | Immunofluorescent analysis of HepG2 cells using PACO46694 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
 | Immunohistochemistry of paraffin-embedded human glioma using PACO46694 at dilution of 1:100. |
| Synonyms: | Protein ZNF365 (DISC1-binding zinc-finger protein) (Protein su48), ZNF365, DBZ KIAA0844 |
| UniProt Protein Function: | Involved in the regulation of neurogenesis. Negatively regulates neurite outgrowth (PubMed:17389905). Involved in the morphogenesis of basket cells in the somatosensory cortex during embryogenesis. Involved in the positive regulation of oligodendrocyte differentiation during postnatal growth. Involved in dendritic arborization, morphogenesis of spine density dendrite, and establishment of postsynaptic dendrite density in cortical pyramidal neurons (). Involved in homologous recombination (HR) repair pathway. Required for proper resolution of DNA double-strand breaks (DSBs) by HR. Is required for recovery of stalled replication forks, and directly contributes to genomic stability. Interacts with PARP1 and mediates MRE11-dependent DNA end resection during replication fork recovery (PubMed:23966166). Contributes to genomic stability by preventing telomere dysfunction (PubMed:23776040). |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes several isoforms which have different expression patterns and functions. Mutation in this gene is associated with uric acid nephrolithiasis (UAN). Alternatively spliced variants, encoding distinct proteins, have been identified. [provided by RefSeq, May 2010] |
| UniProt Code: | Q70YC5 |
| NCBI GenInfo Identifier: | 40789306 |
| NCBI Gene ID: | 22891 |
| NCBI Accession: | NP_955523 |
| UniProt Secondary Accession: | Q70YC5 |
| UniProt Related Accession: | Q70YC5,Q70YC4, Q70YC5 |
| Molecular Weight: | 51kDa |
| NCBI Full Name: | protein ZNF365 isoform C |
| NCBI Synonym Full Names: | zinc finger protein 365 |
| NCBI Official Symbol: | ZNF365 |
| NCBI Official Synonym Symbols: | UAN; Su48; ZNF365D |
| NCBI Protein Information: | protein ZNF365 |
| UniProt Protein Name: | Protein ZNF365 |
| UniProt Synonym Protein Names: | DISC1-binding zinc-finger protein |
| Protein Family: | Protein |
| UniProt Gene Name: | ZNF365 |
| UniProt Entry Name: |
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