ZMIZ1 Antibody (PACO59533)
- SKU:
- PACO59533
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | ZMIZ1 Antibody (PACO59533) |
| Antibody SKU: | PACO59533 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:500-1:1000, IF:1:200-1:500 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Zinc finger MIZ domain-containing protein 1 protein (405-559AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | IHC image of PACO59533 diluted at 1:800 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
 | Immunofluorescence staining of A549 cells with PACO59533 at 1:266, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | Acts as transcriptional coactivator. Increases ligand-dependent transcriptional activity of AR and promotes AR sumoylation. The stimulation of AR activity is dependent upon sumoylation. Involved in transcriptional activation of a subset of NOTCH1 target genes including MYC. Involved in thymocyte and T cell development (By similarity). |
| Synonyms: | Zinc finger MIZ domain-containing protein 1 (PIAS-like protein Zimp10) (Retinoic acid, induced protein 17), ZMIZ1, KIAA1224 RAI17 ZIMP10 |
| UniProt Protein Function: | RAI17: Increases ligand-dependent transcriptional activity of AR and promotes AR sumoylation. The stimulation of AR activity is dependent upon sumoylation. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressorChromosomal Location of Human Ortholog: 10q22.3Cellular Component: intracellular membrane-bound organelle; nucleoplasm |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the PIAS (protein inhibitor of activated STAT) family of proteins. The encoded protein regulates the activity of various transcription factors, including the androgen receptor, Smad3/4, and p53. The encoded protein may also play a role in sumoylation. A translocation between this locus on chromosome 10 and the protein tyrosine kinase ABL1 locus on chromosome 9 has been associated with acute lymphoblastic leukemia. [provided by RefSeq, Mar 2010] |
| UniProt Code: | Q9ULJ6 |
| NCBI GenInfo Identifier: | 56404979 |
| NCBI Gene ID: | 57178 |
| NCBI Accession: | Q9ULJ6.3 |
| UniProt Secondary Accession: | Q9ULJ6,Q5JSH9, Q7Z7E6 |
| UniProt Related Accession: | Q9ULJ6 |
| Molecular Weight: | 107,270 Da |
| NCBI Full Name: | Zinc finger MIZ domain-containing protein 1 |
| NCBI Synonym Full Names: | zinc finger MIZ-type containing 1 |
| NCBI Official Symbol: | ZMIZ1 |
| NCBI Official Synonym Symbols: | MIZ; RAI17; ZIMP10; hZIMP10; TRAFIP10 |
| NCBI Protein Information: | zinc finger MIZ domain-containing protein 1 |
| UniProt Protein Name: | Zinc finger MIZ domain-containing protein 1 |
| UniProt Synonym Protein Names: | PIAS-like protein Zimp10; Retinoic acid-induced protein 17 |
| Protein Family: | Zinc finger MIZ domain-containing protein |
| UniProt Gene Name: | ZMIZ1 |
| UniProt Entry Name: | ZMIZ1_HUMAN |
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