ZFYVE19 Antibody (PACO23501)
- SKU:
- PACO23501
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | ZFYVE19 Antibody (PACO23501) |
| Antibody SKU: | PACO23501 |
| Size: | 100ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000, IHC:1:50-1:100 |
| Species Reactivity: | Human |
| Immunogen: | Synthesized peptide derived from internal of human ZFYVE19. |
| Form: | Liquid |
| Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot analysis of extracts from HT-29 cells, using ZFYVE19 antibody. |
 | Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue using ZFYVE19 antibody. |
| Background: | Key regulator of abscission step in cytokinesis: part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Together with CHMP4C, required to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ZFYVE19/ANCHR and VPS4 and subsequent abscission. |
| Synonyms: | MLL partner containing FYVE domain; MPFYVE; ZFY19; Zinc finger FYVE domain-containing protein 19; |
| UniProt Protein Function: | ZFYVE19: A chromosomal aberration involving ZFYVE19 is associated with acute myeloblastic leukemia (AML). Translocation t(11;15)(q23;q14) with MLL/HRX. 3 isoforms of the human protein are produced by alternative splicing.Protein type: OncoproteinChromosomal Location of Human Ortholog: 15q15.1Cellular Component: centrosome; cleavage furrow; cytoplasm; midbodyMolecular Function: phosphatidylinositol 3-phosphate binding; protein binding; zinc ion bindingBiological Process: abscission; cell cycle; cell division; negative regulation of cytokinesis |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q96K21 |
| NCBI GenInfo Identifier: | 296453076 |
| NCBI Gene ID: | 84936 |
| NCBI Accession: | Q96K21.3 |
| UniProt Secondary Accession: | Q96K21,Q86WC2, Q8WU96, B3KVB2, C9JNF4, H3BUF9 |
| UniProt Related Accession: | Q96K21 |
| Molecular Weight: | 32,963 Da |
| NCBI Full Name: | Abscission/NoCut checkpoint regulator |
| NCBI Synonym Full Names: | zinc finger FYVE-type containing 19 |
| NCBI Official Symbol: | ZFYVE19 |
| NCBI Official Synonym Symbols: | ANCHR; MPFYVE |
| NCBI Protein Information: | abscission/NoCut checkpoint regulator |
| UniProt Protein Name: | Abscission/NoCut checkpoint regulator |
| UniProt Synonym Protein Names: | MLL partner containing FYVE domain; Zinc finger FYVE domain-containing protein 19 |
| Protein Family: | Abscission/NoCut checkpoint regulator |
| UniProt Gene Name: | ZFYVE19 |
| UniProt Entry Name: | ANCHR_HUMAN |
| Antibodies |
| ZFYVE19 Antibody (PACO01720) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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