ZFP57 Antibody (PACO60340)
- SKU:
- PACO60340
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | ZFP57 Antibody (PACO60340) |
| Antibody SKU: | PACO60340 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Recombinant Human Zinc finger protein 57 homolog protein (183-295AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: HepG2 whole cell lysate, 293 whole cell lysate, Mouse brain tissue. All lanes: ZFP57 antibody at 13.6µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 52, 60, 62 kDa. Observed band size: 52 kDa. |
| Background: | Binds to a 5'-TGCCGC-3' consensus sequence and recognizes the methylated CpG within this element (By similarity). Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation. Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions. Required for the establishment of maternal methylation imprints at SNRPN locus. Acts as a transcriptional repressor in Schwann cells. |
| Synonyms: | Zinc finger protein 57 homolog (Zfp-57) (Zinc finger protein 698), ZFP57, C6orf40 ZNF698 |
| UniProt Protein Function: | ZFP57: Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation. Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions. Required for the establishment of maternal methylation imprints at SNRPN locus. Acts as a transcriptional repressor in Schwann cells. Defects in ZFP57 are the cause of transient neonatal diabetes mellitus type 1 (TNDM1). Neonatal diabetes is a form of diabetes mellitus defined by the onset of mild-to- severe hyperglycemia within the first months of life. In about half of the neonates, diabetes is transient and resolves at a median age of 3 months, whereas the rest have a permanent form of diabetes. The major cause of TNDM1 is aberrant expression of imprinted genes at chromosome 6q24, associated in 20% of cases with DNA hypomethylation at the transient neonatal diabetes differentially methylated region (DMR), which lies within the imprinted promoter of the PLAGL1 gene. Over 50% of individuals with transient neonatal diabetes and hypomethylation at 6q24 also show mosaic DNA hypomethylation at other imprinted loci throughout the genome and a range of additional clinical features. Belongs to the krueppel C2H2-type zinc-finger protein family. ZFP57 subfamily. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Transcription factor; C2H2-type zinc finger proteinChromosomal Location of Human Ortholog: 6p22.1Biological Process: DNA methylation during embryonic development; genetic imprintingDisease: Diabetes Mellitus, Transient Neonatal, 1 |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene is a zinc finger protein containing a KRAB domain. Studies in mouse suggest that this protein may function as a transcriptional repressor. Mutations in this gene have been associated with transient neonatal diabetes mellitus type 1 (TNDM1).[provided by RefSeq, Sep 2009] |
| UniProt Code: | Q9NU63 |
| NCBI GenInfo Identifier: | 150416327 |
| NCBI Gene ID: | 346171 |
| NCBI Accession: | Q9NU63.2 |
| UniProt Secondary Accession: | Q9NU63,Q5SSB1, B0S894, B0V254, B2RXJ7 |
| UniProt Related Accession: | Q9NU63 |
| Molecular Weight: | 61,358 Da |
| NCBI Full Name: | Zinc finger protein 57 homolog |
| NCBI Synonym Full Names: | ZFP57 zinc finger protein |
| NCBI Official Symbol: | ZFP57 |
| NCBI Official Synonym Symbols: | TNDM1; ZNF698; C6orf40; bA145L22; bA145L22.2 |
| NCBI Protein Information: | zinc finger protein 57 homolog |
| UniProt Protein Name: | Zinc finger protein 57 homolog |
| UniProt Synonym Protein Names: | Zinc finger protein 698 |
| Protein Family: | Zinc finger protein |
| UniProt Gene Name: | ZFP57 |
| UniProt Entry Name: | ZFP57_HUMAN |
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