ZFP36L2 Antibody (PACO55838)
- SKU:
- PACO55838
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | ZFP36L2 Antibody (PACO55838) |
| Antibody SKU: | PACO55838 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000 |
| Species Reactivity: | Human, Rat |
| Immunogen: | Recombinant Human mRNA decay activator protein ZFP36L2 protein (219-321AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: Rat kidney tissue. All lanes: ZFP36L2 antibody at 2.6µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 52 kDa. Observed band size: 52 kDa. |
| Background: | Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs. Promotes ARE-containing mRNA decay of the low-density lipoprotein (LDL) receptor (LDLR) mRNA in response to phorbol 12-myristate 13-acetate (PMA) treatment in a p38 MAPK-dependent manner. Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs). Plays a role in mature peripheral neuron integrity by promoting ARE-containing mRNA decay of the transcriptional repressor REST mRNA. Plays a role in ovulation and oocyte meiotic maturation by promoting ARE-mediated mRNA decay of the luteinizing hormone receptor LHCGR mRNA. Acts as a negative regulator of erythroid cell differentiation: promotes glucocorticoid-induced self-renewal of erythroid cells by binding mRNAs that are induced or highly expressed during terminal erythroid differentiation and promotes their degradation, preventing erythroid cell differentiation. In association with ZFP36L1 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination process and functional immune cell formation. Together with ZFP36L1 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA. |
| Synonyms: | mRNA decay activator protein ZFP36L2 (Butyrate response factor 2) (EGF-response factor 2) (ERF-2) (TPA-induced sequence 11d) (Zinc finger protein 36, C3H1 type-like 2) (ZFP36-like 2), ZFP36L2, BRF2 ERF2 RNF162C TIS11D |
| UniProt Protein Function: | ZFP36L2: Probable regulatory protein involved in regulating the response to growth factors. RNA-binding protein that binds to 5'UUAUUUAUUU-3' core sequence. Binds to the class II AU-rich element (ARE) in the 3'-UTR of target mRNAs and promotes their deadenylation and degradation. |
| UniProt Protein Details: | Protein type:Transcription factor Chromosomal Location of Human Ortholog: 2p22.3-p21 Cellular Component: cytoplasm; nucleus Molecular Function:AU-rich element binding; transcription factor activity Biological Process: cell proliferation; hemopoiesis; mRNA catabolic process; somatic stem cell division; somatic stem cell maintenance |
| NCBI Summary: | This gene is a member of the TIS11 family of early response genes. Family members are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This putative nuclear transcription factor most likely functions in regulating the response to growth factors. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P47974 |
| NCBI GenInfo Identifier: | 146291085 |
| NCBI Gene ID: | 678 |
| NCBI Accession: | P47974.3 |
| UniProt Secondary Accession: | P47974,Q53TB4, Q9BSJ3, |
| UniProt Related Accession: | P47974 |
| Molecular Weight: | 51,063 Da |
| NCBI Full Name: | Zinc finger protein 36, C3H1 type-like 2 |
| NCBI Synonym Full Names: | ZFP36 ring finger protein like 2 |
| NCBI Official Symbol: | ZFP36L2 |
| NCBI Official Synonym Symbols: | BRF2; ERF2; ERF-2; TIS11D; RNF162C |
| NCBI Protein Information: | zinc finger protein 36, C3H1 type-like 2 |
| UniProt Protein Name: | Zinc finger protein 36, C3H1 type-like 2 |
| UniProt Synonym Protein Names: | Butyrate response factor 2; EGF-response factor 2; ERF-2; Protein TIS11D |
| Protein Family: | mRNA decay activator protein |
| UniProt Gene Name: | ZFP36L2 |
| UniProt Entry Name: | TISD_HUMAN |
| Antibodies | ELISA Kits |
| ZFP36L2 Antibody (PACO01632) | TISD Colorimetric Cell-Based ELISA |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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