ZC3H8 Antibody (PACO23500)
- SKU:
- PACO23500
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | ZC3H8 Antibody (PACO23500) |
| Antibody SKU: | PACO23500 |
| Size: | 100ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000, IHC:1:50-1:100 |
| Species Reactivity: | Human |
| Immunogen: | Synthesized peptide derived from internal of human ZC3H8. |
| Form: | Liquid |
| Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot analysis of extracts from HepG2 cells, using ZC3H8 antibody. |
 | Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue, using ZC3H8 antibody. |
| Background: | Acts as a transcriptional repressor of the GATA3 promoter. Sequence-specific DNA-binding factor that binds to the 5'-AGGTCTC-3' sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene By similarity. Induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocyte homeostasis. |
| Synonyms: | Zinc finger CCCH domain-containing protein 8; ZC3H8; ZC3HDC8; |
| UniProt Protein Function: | ZC3H8: Acts as a transcriptional repressor of the GATA3 promoter. Sequence-specific DNA-binding factor that binds to the 5'-AGGTCTC-3' sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene. Induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocyte homeostasis.Protein type: DNA-bindingChromosomal Location of Human Ortholog: 2q13Cellular Component: Cajal body; nucleoplasm; nucleus; transcription elongation factor complexMolecular Function: protein binding; sequence-specific DNA binding; transcription factor activityBiological Process: negative regulation of T cell differentiation in the thymus; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase III promoter; response to antibiotic; snRNA transcription from RNA polymerase II promoter; snRNA transcription from RNA polymerase III promoter; T cell homeostasis |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q8N5P1 |
| NCBI GenInfo Identifier: | 47117585 |
| NCBI Gene ID: | 84524 |
| NCBI Accession: | Q8N5P1.2 |
| UniProt Secondary Accession: | Q8N5P1,Q9BZ75 |
| UniProt Related Accession: | Q8N5P1 |
| Molecular Weight: | 33,576 Da |
| NCBI Full Name: | Zinc finger CCCH domain-containing protein 8 |
| NCBI Synonym Full Names: | zinc finger CCCH-type containing 8 |
| NCBI Official Symbol: | ZC3H8 |
| NCBI Official Synonym Symbols: | Fliz1; ZC3HDC8 |
| NCBI Protein Information: | zinc finger CCCH domain-containing protein 8 |
| UniProt Protein Name: | Zinc finger CCCH domain-containing protein 8 |
| UniProt Synonym Protein Names: | |
| Protein Family: | Zinc finger CCCH domain-containing protein |
| UniProt Gene Name: | ZC3H8 |
| UniProt Entry Name: | ZC3H8_HUMAN |
| Antibodies |
| ZC3H8 Antibody (PACO00808) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
Related Products
SIM1 Antibody
Overview Product Name:SIM1 AntibodyProduct Code:PACO64949Size:50µLTarget Names:SIM1Species Reactivity:HumanHost
eutC Antibody
Overview Product Name:eutC AntibodyProduct Code:PACO64709Size:50µLTarget Names:eutCSpecies Reactivity:Escherichia coli
EPHA10 Antibody
Overview Product Name:EPHA10 AntibodyProduct Code:PACO64693Size:50µLTarget Names:EPHA10Species Reactivity:HumanH
otsB Antibody
Overview Product Name:otsB AntibodyProduct Code:PACO64885Size:50µLTarget Names:otsBSpecies Reactivity:Escherichia coli