ZC3H8 Antibody (PACO00808)
- SKU:
- PACO00808
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | ZC3H8 Antibody |
| Antibody SKU: | PACO00808 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | WB:1:500-1:2000, IHC:1:100-1:300 |
| Species Reactivity: | Human |
| Immunogen: | synthesized peptide derived from the Internal region of human Fliz1. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | ZC3H8; ZC3HDC8; Zinc finger CCCH domain-containing protein 8 |
| UniProt Protein Function: | ZC3H8: Acts as a transcriptional repressor of the GATA3 promoter. Sequence-specific DNA-binding factor that binds to the 5'-AGGTCTC-3' sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene. Induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocyte homeostasis.Protein type: DNA-bindingChromosomal Location of Human Ortholog: 2q13Cellular Component: Cajal body; nucleoplasm; nucleus; transcription elongation factor complexMolecular Function: protein binding; sequence-specific DNA binding; transcription factor activityBiological Process: negative regulation of T cell differentiation in the thymus; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase III promoter; response to antibiotic; snRNA transcription from RNA polymerase II promoter; snRNA transcription from RNA polymerase III promoter; T cell homeostasis |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q8N5P1 |
| NCBI GenInfo Identifier: | 47117585 |
| NCBI Gene ID: | 84524 |
| NCBI Accession: | Q8N5P1.2 |
| UniProt Secondary Accession: | Q8N5P1,Q9BZ75 |
| UniProt Related Accession: | Q8N5P1 |
| Molecular Weight: | 33,576 Da |
| NCBI Full Name: | Zinc finger CCCH domain-containing protein 8 |
| NCBI Synonym Full Names: | zinc finger CCCH-type containing 8 |
| NCBI Official Symbol: | ZC3H8 |
| NCBI Official Synonym Symbols: | Fliz1; ZC3HDC8 |
| NCBI Protein Information: | zinc finger CCCH domain-containing protein 8 |
| UniProt Protein Name: | Zinc finger CCCH domain-containing protein 8 |
| UniProt Synonym Protein Names: | |
| Protein Family: | Zinc finger CCCH domain-containing protein |
| UniProt Gene Name: | ZC3H8 |
| UniProt Entry Name: | ZC3H8_HUMAN |
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