ZBED3 Antibody (PACO63175)
- SKU:
- PACO63175
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | ZBED3 Antibody (PACO63175) |
| Antibody SKU: | PACO63175 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Zinc finger BED domain-containing protein 3 protein (1-234AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | Antigen Affinity Purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | IHC image of PACO63175 diluted at 1:100 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
| Background: | Acts as a positive regulator in the activation of the canonical Wnt/beta-catenin signaling pathway by stabilizing cytoplasmic beta-catenin. Involved in transcription activation of Wnt target gene expression (By similarity). |
| Synonyms: | Zinc finger BED domain-containing protein 3 (Axin-interacting protein), ZBED3 |
| UniProt Protein Function: | ZBED3: Acts as a positive regulator in the activation of the canonical Wnt/beta-catenin signaling pathway by stabilizing cytoplasmic beta-catenin. Involved in transcription activation of Wnt target gene expression. Interacts with AXIN1; the interaction is direct, enhanced by protein kinase GSK3B and casein kinase CSNK1E activities and decreases GSK3B-induced beta-catenin serine and threonine phosphorylations |
| UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: 5q13.3 Cellular Component: membrane; cytosol Molecular Function:DNA binding; metal ion binding Biological Process: Wnt receptor signaling pathway; negative regulation of protein amino acid phosphorylation; protein stabilization; positive regulation of transcription from RNA polymerase II promoter |
| UniProt Code: | Q96IU2 |
| NCBI GenInfo Identifier: | 14150185 |
| NCBI Gene ID: | |
| NCBI Accession: | NP_115743 |
| Molecular Weight: | |
| NCBI Full Name: | zinc finger BED domain-containing protein 3 |
| UniProt Protein Name: | Zinc finger BED domain-containing protein 3 |
| UniProt Synonym Protein Names: | Axin-interacting protein |
| UniProt Gene Name: | ZBED3 |
| UniProt Entry Name: | ZBED3_HUMAN |
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