YTHDF2 Polyclonal Antibody
- SKU:
- CAB24287
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IHC
Description
| Product Name: | YTHDF2 Polyclonal Antibody |
| Product Code: | CAB24287 |
| Reactivity: | Human |
| Applications: | Western blotting, Immunohistochemistry |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human |
| Tested Applications: | WB, IHC-P, ELISA |
| Key Applications: | Western blotting, Immunohistochemistry |
| Recommended Dilution: | WB 1:500-1:1000, IHC-P 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3. |
| Positive Samples: | HeLa |
This gene encodes a member of the YTH (YT521-B homology) superfamily containing YTH domain. The YTH domain is typical for the eukaryotes and is particularly abundant in plants. The YTH domain is usually located in the middle of the protein sequence and may function in binding to RNA. In addition to a YTH domain, this protein has a proline rich region which may be involved in signal transduction. An Alu-rich domain has been identified in one of the introns of this gene, which is thought to be associated with human longevity. In addition, reciprocal translocations between this gene and the Runx1 (AML1) gene on chromosome 21 has been observed in patients with acute myeloid leukemia. This gene was initially mapped to chromosome 14, which was later turned out to be a pseudogene. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 153-253AA of human YTHDF2 (NP_001166599.1). |
| Sequence: | YAYAP SSLGG AMIDG QSAFA NETLN KAPGM NTIDQ GMAAL KLGST EVASN VPKVV GSAVG SGSIT SNIVA SNSLP PATIA PPKPA SWADI ASKPA KQQPK L |
| Synonyms: | DF2, CAHL, HGRG8, NY-REN-2 |
| Calculated MW: | 62kDa |
| Observed MW: | 65kDa |
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