YAF2 Antibody (PACO37670)
- SKU:
- PACO37670
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | YAF2 Antibody (PACO37670) |
| Antibody SKU: | PACO37670 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human YY1-associated factor 2 protein (1-204AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human colon cancer using PACO37670 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human glioma using PACO37670 at dilution of 1:100. |
| Background: | Binds to MYC and inhibits MYC-mediated transactivation. Also binds to MYCN and enhances MYCN-dependent transcriptional activation. Increases calpain 2-mediated proteolysis of YY1 in vitro. Component of the E2F6.com-1 complex, a repressive complex that methylates 'Lys-9' of histone H3, suggesting that it is involved in chromatin-remodeling. |
| Synonyms: | YY1-associated factor 2, YAF2 |
| UniProt Protein Function: | YAF2: Binds to MYC and inhibits MYC-mediated transactivation. Also binds to MYCN and enhances MYCN-dependent transcriptional activation. Increases calpain 2-mediated proteolysis of YY1 in vitro. Component of the E2F6.com-1 complex, a repressive complex that methylates 'Lys-9' of histone H3, suggesting that it is involved in chromatin-remodeling. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Transcription, coactivator/corepressorChromosomal Location of Human Ortholog: 12q12Cellular Component: nucleoplasm; cytoplasm; nucleusMolecular Function: protein binding; zinc ion binding; transcription coactivator activity; transcription corepressor activityBiological Process: transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; negative regulation of transcription, DNA-dependent |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a zinc finger containing protein that functions in the regulation of transcription. This protein was identified as an interacting partner of transcriptional repressor protein Yy1, and also interacts with other transcriptional regulators, including Myc and Polycomb. This protein can promote proteolysis of Yy1. Multiple alternatively spliced transcript variants have been found. [provided by RefSeq, Feb 2016] |
| UniProt Code: | Q8IY57 |
| NCBI GenInfo Identifier: | 60218897 |
| NCBI Gene ID: | 10138 |
| NCBI Accession: | NP_005739 |
| UniProt Secondary Accession: | Q8IY57 |
| UniProt Related Accession: | Q8IY57 |
| Molecular Weight: | 20kDa |
| NCBI Full Name: | YY1-associated factor 2 isoform 2 |
| NCBI Synonym Full Names: | YY1 associated factor 2 |
| NCBI Official Symbol: | YAF2 |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | YY1-associated factor 2 |
| UniProt Protein Name: | YY1-associated factor 2 |
| UniProt Synonym Protein Names: | |
| Protein Family: | YY1-associated factor |
| UniProt Gene Name: | YAF2 |
| UniProt Entry Name: | YAF2_HUMAN |
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