Description
Product Name: | Xanthine Oxidase (XDH) Monoclonal Antibody |
Product Code: | CAB22335 |
Reactivity: | Mouse, Rat |
Applications: | Western blotting |
Host Species: | Rabbit |
Purification Method: | Affinity purification |
Isotype: | IgG |
Clone No: | ARC51279 |
Reactivity: | Mouse, Rat |
Tested Applications: | WB, ELISA |
Key Applications: | Western blotting |
Recommended Dilution: | WB 1:500-1:1000, IF/ICC 1:50-1:200 |
Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
Positive Samples: | Mouse lung, Rat lung, Rat liver, Mouse heart |
Cellular Location: | Cytoplasm, Peroxisome, Secreted |
Xanthine dehydrogenase belongs to the group of molybdenum-containing hydroxylases involved in the oxidative metabolism of purines. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Xanthine dehydrogenase can be converted to xanthine oxidase by reversible sulfhydryl oxidation or by irreversible proteolytic modification. Defects in xanthine dehydrogenase cause xanthinuria, may contribute to adult respiratory stress syndrome, and may potentiate influenza infection through an oxygen metabolite-dependent mechanism.
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1000-1100 of human Xanthine Oxidase (XDH) (NP_000370.2). |
Sequence: | CIIPT KFGIS FTVPF LNQAG ALLHV YTDGS VLLTH GGTEM GQGLH TKMVQ VASRA LKIPT SKIYI SETST NTVPN TSPTA ASVSA DLNGQ AVYAA CQTIL K |
Synonyms: | XO, XOR, XAN1 |
Calculated MW: | 146kDa |
Observed MW: | 152kDa |