WSS1 Antibody (PACO52186)
- SKU:
- PACO52186
- Product Type:
- Antibody
- Reactivity:
- Yeast - Saccharomyces cerevisiae
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | WSS1 Antibody (PACO52186) |
| Antibody SKU: | PACO52186 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA |
| Recommended Dilutions: | |
| Species Reactivity: | Saccharomyces cerevisiae |
| Immunogen: | Recombinant Saccharomyces cerevisiae DNA-dependent metalloprotease WSS1 protein (1-269AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Background: | Metalloendopeptidase that acts selectively on DNA-binding proteins. DNA is needed to bring the protease and substrates together to enable proteolysis. Involved in the repair of toxic DNA-protein cross-links (DPCs) such as covalently trapped topoisomerase 1 (TOP1) adducts on DNA lesions or DPCs induced by reactive compounds such as formaldehyde. Involved in DNA damage response and processing of stalled or collapsed replication forks by removing the covalently trapped TOP1 from chromatin. DPC proteolysis enables the repair of the lesions via downstream DNA repair pathways. May be recruited to DPCs via the SUMOylation of substrate proteins at damaged DNA sites. |
| Synonyms: | DNA-dependent metalloprotease WSS1 (EC 3.4.24) (DNA damage response protein WSS1) (SUMO-dependent isopeptidase WSS1) (Weak suppressor of SMT3 protein 1), WSS1 |
| UniProt Protein Function: | Metalloendopeptidase that acts selectively on DNA-binding proteins. DNA is needed to bring the protease and substrates together to enable proteolysis. Involved in the repair of toxic DNA-protein cross-links (DPCs) such as covalently trapped topoisomerase 1 (TOP1) adducts on DNA lesions or DPCs induced by reactive compounds such as formaldehyde. Involved in DNA damage response and processing of stalled or collapsed replication forks by removing the covalently trapped TOP1 from chromatin. DPC proteolysis enables the repair of the lesions via downstream DNA repair pathways. May be recruited to DPCs via the SUMOylation of substrate proteins at damaged DNA sites. |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | P38838 |
| NCBI GenInfo Identifier: | 6321926 |
| NCBI Gene ID: | 856536 |
| NCBI Accession: | NP_012002.1 |
| UniProt Secondary Accession: | P38838,D3DL83 |
| UniProt Related Accession: | P38838 |
| Molecular Weight: | 30,627 Da |
| NCBI Full Name: | metalloendopeptidase WSS1 |
| NCBI Synonym Full Names: | |
| NCBI Official Symbol: | WSS1 |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | metalloendopeptidase WSS1 |
| UniProt Protein Name: | DNA-dependent metalloprotease WSS1 |
| UniProt Synonym Protein Names: | DNA damage response protein WSS1; SUMO-dependent isopeptidase WSS1; Weak suppressor of SMT3 protein 1 |
| Protein Family: | DNA-dependent metalloprotease |
| UniProt Gene Name: | WSS1 |
| UniProt Entry Name: |
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