WNT8B Antibody (PACO20920)
- SKU:
- PACO20920
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | WNT8B Antibody (PACO20920) |
| Antibody SKU: | PACO20920 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:2000, IHC:1:10-1:50 |
| Species Reactivity: | Human |
| Immunogen: | Synthetic peptide of human WNT8B |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO20920(WNT8B Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 95%, 86% and 71% amino acid, identity to the mouse, zebrafish and Xenopus Wnt8B proteins, respectively. The expression patterns of the human and mouse genes appear identical and are restricted to the developing brain. The chromosomal location of this gene to 10q24 suggests it as a candidate gene for partial epilepsy. |
| Synonyms: | wingless-type MMTV integration site family, member 8B |
| UniProt Protein Function: | WNT8B: Ligand for members of the frizzled family of seven transmembrane receptors. May play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus. Belongs to the Wnt family.Protein type: Secreted; Secreted, signal peptideChromosomal Location of Human Ortholog: 10q24Cellular Component: extracellular region; extracellular spaceMolecular Function: frizzled bindingBiological Process: cell fate commitment; determination of dorsal identity; gastrulation; nervous system development; neuron differentiation; signal transduction; Wnt receptor signaling pathway |
| UniProt Protein Details: | |
| NCBI Summary: | The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 95%, 86% and 71% amino acid identity to the mouse, zebrafish and Xenopus Wnt8B proteins, respectively. The expression patterns of the human and mouse genes appear identical and are restricted to the developing brain. The chromosomal location of this gene to 10q24 suggests it as a candidate gene for partial epilepsy. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q93098 |
| NCBI GenInfo Identifier: | 66774217 |
| NCBI Gene ID: | 7479 |
| NCBI Accession: | Q93098.3 |
| UniProt Secondary Accession: | Q93098,O00771, Q5VX55, Q8WYK9 |
| UniProt Related Accession: | Q93098 |
| Molecular Weight: | 38,721 Da |
| NCBI Full Name: | Protein Wnt-8b |
| NCBI Synonym Full Names: | Wnt family member 8B |
| NCBI Official Symbol: | WNT8B |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | protein Wnt-8b |
| UniProt Protein Name: | Protein Wnt-8b |
| UniProt Synonym Protein Names: | |
| Protein Family: | Protein |
| UniProt Gene Name: | WNT8B |
| UniProt Entry Name: | WNT8B_HUMAN |
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