WNT8A Antibody (PACO58472)
- SKU:
- PACO58472
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | WNT8A Antibody (PACO58472) |
| Antibody SKU: | PACO58472 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:200-1:500 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Protein Wnt-8a protein (223-309AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | IHC image of PACO58472 diluted at 1:200 and staining in paraffin-embedded human gastric cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
 | IHC image of PACO58472 diluted at 1:200 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
| Background: | Ligand for members of the frizzled family of seven transmembrane receptors. May play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus. |
| Synonyms: | Protein Wnt-8a (Protein Wnt-8d), WNT8A, WNT8D |
| UniProt Protein Function: | WNT8A: Ligand for members of the frizzled family of seven transmembrane receptors. May play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus. Belongs to the Wnt family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Secreted; Secreted, signal peptide; Extracellular matrixChromosomal Location of Human Ortholog: 5q31Cellular Component: extracellular space; proteinaceous extracellular matrix; extracellular regionMolecular Function: frizzled binding; receptor agonist activityBiological Process: neuron differentiation; response to retinoic acid; neural crest cell fate commitment; palate development; Wnt receptor signaling pathway through beta-catenin |
| UniProt Protein Details: | |
| NCBI Summary: | The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family, and may be implicated in development of early embryos as well as germ cell tumors. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2014] |
| UniProt Code: | Q9H1J5 |
| NCBI GenInfo Identifier: | 14495176 |
| NCBI Gene ID: | 7478 |
| NCBI Accession: | BAB60960.1 |
| UniProt Secondary Accession: | Q9H1J5,Q96S51 |
| UniProt Related Accession: | Q9H1J5 |
| Molecular Weight: | 39,527 Da |
| NCBI Full Name: | WNT8A |
| NCBI Synonym Full Names: | wingless-type MMTV integration site family, member 8A |
| NCBI Official Symbol: | WNT8A |
| NCBI Official Synonym Symbols: | WNT8D |
| NCBI Protein Information: | protein Wnt-8a; WNT8d; protein Wnt-8d |
| UniProt Protein Name: | Protein Wnt-8a |
| UniProt Synonym Protein Names: | Protein Wnt-8d |
| Protein Family: | Protein |
| UniProt Gene Name: | WNT8A |
| UniProt Entry Name: | WNT8A_HUMAN |
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