Antibody Name:	WNT6 Antibody (PACO20918)
Antibody SKU:	PACO20918
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, IHC
Recommended Dilutions:	ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:	Human, Mouse
Immunogen:	Synthetic peptide of human WNT6

Form:	Liquid
Storage Buffer:	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:	Antigen affinity purification
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO20918(WNT6 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200).
	The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO20918(WNT6 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200).

Background:

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is overexpressed in cervical cancer cell line and strongly coexpressed with another family member, WNT10A, in colorectal cancer cell line. The gene overexpression may play key roles in carcinogenesis. This gene and the WNT10A gene are clustered in the chromosome 2q35 region. The protein encoded by this gene is 97% identical to the mouse Wnt6 protein at the amino acid, level.

Synonyms:

wingless-type MMTV integration site family, member 6

UniProt Protein Function:	WNT6: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Belongs to the Wnt family.
UniProt Protein Details:	Protein type:Secreted; Extracellular matrix; Cell development/differentiation; Secreted, signal peptide Chromosomal Location of Human Ortholog: 2q35 Cellular Component: endoplasmic reticulum lumen; extracellular region; extracellular space; Golgi lumen; plasma membrane Molecular Function:frizzled binding Biological Process: cell fate commitment; neuron differentiation; odontogenesis of dentine-containing teeth; Wnt receptor signaling pathway
NCBI Summary:	The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is overexpressed in cervical cancer cell line and strongly coexpressed with another family member, WNT10A, in colorectal cancer cell line. The gene overexpression may play key roles in carcinogenesis. This gene and the WNT10A gene are clustered in the chromosome 2q35 region. The protein encoded by this gene is 97% identical to the mouse Wnt6 protein at the amino acid level. [provided by RefSeq, Jul 2008]
UniProt Code:	Q9Y6F9
NCBI GenInfo Identifier:	14424016
NCBI Gene ID:	7475
NCBI Accession:	Q9Y6F9.2
UniProt Secondary Accession:	Q9Y6F9,Q9H1J6, Q9H238,
UniProt Related Accession:	Q9Y6F9
Molecular Weight:	39,721 Da
NCBI Full Name:	Protein Wnt-6
NCBI Synonym Full Names:	Wnt family member 6
NCBI Official Symbol:	WNT6
NCBI Protein Information:	protein Wnt-6
UniProt Protein Name:	Protein Wnt-6
Protein Family:	Protein
UniProt Gene Name:	WNT6
UniProt Entry Name:	WNT6_HUMAN