Antibody Name:	WNK1 Antibody (PACO20884)
Antibody SKU:	PACO20884
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, IHC
Recommended Dilutions:	ELISA:1:1000-1:2000, IHC:1:10-1:50
Species Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide of human WNK1

Form:	Liquid
Storage Buffer:	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:	Antigen affinity purification
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO20884(WNK1 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200).
	The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO20884(WNK1 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200).

Background:

This gene encodes a member of the WNK subfamily of serine/threonine protein kinases. The encoded protein may be a key regulator of blood pressure by controlling the transport of sodium and chloride ions. Mutations in this gene have been associated with pseudohypoaldosteronism type II and hereditary sensory neuropathy type II. Alternatively spliced transcript variants encoding different isoforms have been described but the full-length nature of all of them has yet to be determined.

Synonyms:

WNK lysine deficient protein kinase 1

UniProt Protein Function:	WNK1: a serine-threonine protein kinase that controls sodium and chloride ion transport. May regulate the activity of the thiazide-sensitive Na-Cl cotransporter SLC12A3 by phosphorylation. May also play a role in actin cytoskeletal reorganization.
UniProt Protein Details:	Protein type:EC 2.7.11.1; Protein kinase, Other; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Other group; Wnk family Chromosomal Location of Human Ortholog: 12p13.3 Cellular Component: cytoplasm Molecular Function:protein serine/threonine kinase activity; protein binding; chloride channel inhibitor activity; protein kinase inhibitor activity; ATP binding; phosphatase binding Biological Process: regulation of cellular process; peptidyl-threonine phosphorylation; negative regulation of protein kinase activity; neuron development; ion transport; protein amino acid phosphorylation Disease: Neuropathy, Hereditary Sensory And Autonomic, Type Iia; Pseudohypoaldosteronism, Type Iic
NCBI Summary:	This gene encodes a member of the WNK subfamily of serine/threonine protein kinases. The encoded protein may be a key regulator of blood pressure by controlling the transport of sodium and chloride ions. Mutations in this gene have been associated with pseudohypoaldosteronism type II and hereditary sensory neuropathy type II. Alternatively spliced transcript variants encoding different isoforms have been described but the full-length nature of all of them has yet to be determined.[provided by RefSeq, May 2010]
UniProt Code:	Q9H4A3
NCBI GenInfo Identifier:	296453029
NCBI Gene ID:	65125
NCBI Accession:	Q9H4A3.2
UniProt Secondary Accession:	Q9H4A3,O15052, P54963, Q4VBX9, Q6IFS5, Q86WL5, Q8N673 A1L4B0, C5HTZ5, C5HTZ6, C5HTZ7, H6WZW3,
UniProt Related Accession:	Q9H4A3
Molecular Weight:	2382
NCBI Full Name:	Serine/threonine-protein kinase WNK1
NCBI Synonym Full Names:	WNK lysine deficient protein kinase 1
NCBI Official Symbol:	WNK1
NCBI Official Synonym Symbols:	KDP; PSK; p65; HSN2; HSAN2; PRKWNK1; PPP1R167
NCBI Protein Information:	serine/threonine-protein kinase WNK1; erythrocyte 65 kDa protein; protein kinase with no lysine 1; prostate-derived sterile 20-like kinase; WNK lysine deficient protein kinase 1 isoform; protein phosphatase 1, regulatory subunit 167
UniProt Protein Name:	Serine/threonine-protein kinase WNK1
UniProt Synonym Protein Names:	Erythrocyte 65 kDa protein; p65; Kinase deficient protein; Protein kinase lysine-deficient 1; Protein kinase with no lysine 1; hWNK1
Protein Family:	Serine/threonine-protein kinase
UniProt Gene Name:	WNK1
UniProt Entry Name:	WNK1_HUMAN

Antibodies	ELISA Kits
Anti-WNK1 Antibody (CAB14196)	WNK1 (Phospho-Thr58) Colorimetric Cell-Based ELISA Kit
Anti-WNK1 Antibody (CAB2569)
Anti-WNK1 Antibody (CAB4223)
Phospho-WNK1 (T60) Antibody (PACO00312)
WNK1 Antibody (PACO01702)