WIPF2 Antibody (PACO59249)
- SKU:
- PACO59249
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | WIPF2 Antibody (PACO59249) |
| Antibody SKU: | PACO59249 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:500-1:1000 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human WAS/WASL-interacting protein family member 2 protein (18-176AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | IHC image of PACO59249 diluted at 1:500 and staining in paraffin-embedded human cervical cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
 | IHC image of PACO59249 diluted at 1:500 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
| Background: | Plays an active role in the formation of cell surface protrusions downstream of activated PDGFB receptors. Plays an important role in actin-microspike formation through cooperation with WASL. May cooperate with WASP and WASL to induce mobilization and reorganization of the actin filament system. |
| Synonyms: | WAS/WASL-interacting protein family member 2 (WASP-interacting protein-related protein) (WIP- and CR16-homologous protein) (WIP-related protein), WIPF2, WICH WIRE |
| UniProt Protein Function: | WIRE: Plays an active role in the formation of cell surface protrusions downstream of activated PDGFB receptors. Plays an important role in actin-microspike formation through cooperation with WASL. May cooperate with WASP and WASL to induce mobilization and reorganization of the actin filament system. Belongs to the verprolin family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Adaptor/scaffoldChromosomal Location of Human Ortholog: 17q21.2Cellular Component: actin filament; cytosolMolecular Function: actin filament binding; protein bindingBiological Process: actin cortical patch assembly; actin cortical patch localization; actin filament-based movement; endocytosis; positive regulation of actin nucleation; regulation of cell shape |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a WASP interacting protein (WIP)-related protein. It has been shown that this protein has a role in the WASP-mediated organization of the actin cytoskeleton and that this protein is a potential link between the activated platelet-derived growth factor receptor and the actin polymerization machinery. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q8TF74 |
| NCBI GenInfo Identifier: | 60390855 |
| NCBI Gene ID: | 147179 |
| NCBI Accession: | Q8TF74.1 |
| UniProt Secondary Accession: | Q8TF74,Q658J8, Q71RE1, Q8TE44, A8K0L3 |
| UniProt Related Accession: | Q8TF74 |
| Molecular Weight: | 30,840 Da |
| NCBI Full Name: | WAS/WASL-interacting protein family member 2 |
| NCBI Synonym Full Names: | WAS/WASL interacting protein family member 2 |
| NCBI Official Symbol: | WIPF2 |
| NCBI Official Synonym Symbols: | WICH; WIRE |
| NCBI Protein Information: | WAS/WASL-interacting protein family member 2 |
| UniProt Protein Name: | WAS/WASL-interacting protein family member 2 |
| UniProt Synonym Protein Names: | WASP-interacting protein-related protein; WIP- and CR16-homologous protein; WIP-related protein |
| Protein Family: | WAS/WASL-interacting protein family |
| UniProt Gene Name: | WIPF2 |
| UniProt Entry Name: | WIPF2_HUMAN |
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