WDYHV1 Antibody (PACO39594)
- SKU:
- PACO39594
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | WDYHV1 Antibody (PACO39594) |
| Antibody SKU: | PACO39594 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:2000 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Recombinant Human Protein N-terminal glutamine amidohydrolase protein (1-205AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot. All lanes: WDYHV1 antibody at 6µg/ml. Lane 1: Mouse heart tissue. Lane 2: MCF-7 whole cell lysate. Lane 3: U251 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 24, 17 kDa. Observed band size: 24 kDa. |
| Background: | Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position. Does not deaminate acetylated N-terminal glutamine. With the exception of proline, all tested second-position residues on substrate peptides do not greatly influence the activity. In contrast, a proline at position 2, virtually abolishes deamidation of N-terminal glutamine (By similarity). |
| Synonyms: | Protein N-terminal glutamine amidohydrolase (EC 3.5.1.122) (Protein NH2-terminal glutamine deamidase) (N-terminal Gln amidase) (Nt(Q)-amidase) (WDYHV motif-containing protein 1), WDYHV1, C8orf32 NTAQ1 |
| UniProt Protein Function: | WDYHV1: Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N- terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C- terminal glutamine and does not act on non-glutamine residues in any position. Does not deaminate acetylated N-terminal glutamine. With the exception of proline, all tested second-position residues on substrate peptides do not greatly influence the activity. In contrast, a proline at position 2, virtually abolishes deamidation of N-terminal glutamine. Belongs to the NTAQ1 family.Protein type: EC 3.5.1.-Chromosomal Location of Human Ortholog: 8q24.13Cellular Component: cytosol; nucleusMolecular Function: protein bindingBiological Process: protein modification process |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q96HA8 |
| NCBI GenInfo Identifier: | 152112225 |
| NCBI Gene ID: | 55093 |
| NCBI Accession: | Q96HA8.2 |
| UniProt Secondary Accession: | Q96HA8,Q9NW95, B4DE68 |
| UniProt Related Accession: | Q96HA8 |
| Molecular Weight: | 16,736 Da |
| NCBI Full Name: | Protein N-terminal glutamine amidohydrolase |
| NCBI Synonym Full Names: | WDYHV motif containing 1 |
| NCBI Official Symbol: | WDYHV1 |
| NCBI Official Synonym Symbols: | C8orf32 |
| NCBI Protein Information: | protein N-terminal glutamine amidohydrolase |
| UniProt Protein Name: | Protein N-terminal glutamine amidohydrolase |
| UniProt Synonym Protein Names: | Protein NH2-terminal glutamine deamidase; N-terminal Gln amidase; Nt(Q)-amidase; WDYHV motif-containing protein 1 |
| Protein Family: | |
| UniProt Gene Name: | WDYHV1 |
| UniProt Entry Name: | NTAQ1_HUMAN |
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