WDR45B Antibody (PACO20876)
- SKU:
- PACO20876
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | WDR45B Antibody (PACO20876) |
| Antibody SKU: | PACO20876 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:30-1:150 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Synthetic peptide of human WDR45B |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO20876(WDR45B Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | This gene encodes a member of the WIPI or SVP1 family of WD40 repeat-containing proteins. The protein contains seven WD40 repeats that are thought to fold into a beta-propeller structure that mediates protein-protein interactions, and a conserved motif for interaction with phospholipids. The human genome contains several pseudogenes of this gene. |
| Synonyms: | WD repeat domain 45B |
| UniProt Protein Function: | WDR45B: an ubiquitously expressed WD40 repeat protein. Up-regulated in a variety of tumor tissues including ovarian and uterine cancers. WD40 repeats are found in a number of eukaryotic proteins that coordinate multi-protein complex assemblies. WD40 proteins are implicated in many functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly.Protein type: Adaptor/scaffoldChromosomal Location of Human Ortholog: 17q25.3Cellular Component: extrinsic to membrane; pre-autophagosomal structure membrane; cytosolMolecular Function: phosphatidylinositol 3-phosphate bindingBiological Process: protein amino acid lipidation; mitochondrion degradation; autophagic vacuole formation; cellular response to nitrogen starvation |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the WIPI or SVP1 family of WD40 repeat-containing proteins. The protein contains seven WD40 repeats that are thought to fold into a beta-propeller structure that mediates protein-protein interactions, and a conserved motif for interaction with phospholipids. The human genome contains several pseudogenes of this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q5MNZ6 |
| NCBI GenInfo Identifier: | 85542094 |
| NCBI Gene ID: | 56270 |
| NCBI Accession: | Q5MNZ6.2 |
| UniProt Secondary Accession: | Q5MNZ6,O95328, Q2MCP6, Q6IBN2 |
| UniProt Related Accession: | Q5MNZ6 |
| Molecular Weight: | 38,122 Da |
| NCBI Full Name: | WD repeat domain phosphoinositide-interacting protein 3 |
| NCBI Synonym Full Names: | WD repeat domain 45B |
| NCBI Official Symbol: | WDR45B |
| NCBI Official Synonym Symbols: | WIPI3; WDR45L; WIPI-3 |
| NCBI Protein Information: | WD repeat domain phosphoinositide-interacting protein 3; WDR45-like protein; WIPI49-like protein; WD repeat protein 45-like; WD repeat-containing protein 45B; WD repeat-containing protein 45-like |
| UniProt Protein Name: | WD repeat domain phosphoinositide-interacting protein 3 |
| UniProt Synonym Protein Names: | WD repeat-containing protein 45-like; WDR45-like protein; WD repeat-containing protein 45B; WIPI49-like protein |
| Protein Family: | |
| UniProt Gene Name: | WDR45B |
| UniProt Entry Name: | WIPI3_HUMAN |
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