WDR41 Antibody (PACO63875)
- SKU:
- PACO63875
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | WDR41 Antibody (PACO63875) |
| Antibody SKU: | PACO63875 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human WD repeat-containing protein 41 protein (7-284AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunofluorescence staining of U251 cells with PACO63875 at 1:166, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | Non-catalytic component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy. The C9orf72-SMCR8 complex promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation. The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and inhibiting its protein kinase activity. |
| Synonyms: | WD repeat-containing protein 41, WDR41 |
| UniProt Protein Function: | WDR41: 2 isoforms of the human protein are produced by alternative splicingChromosomal Location of Human Ortholog: 5q13.3Cellular Component: lysosomal membrane |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q9HAD4 |
| NCBI GenInfo Identifier: | 134047969 |
| NCBI Gene ID: | 55255 |
| NCBI Accession: | Q9HAD4.3 |
| UniProt Secondary Accession: | Q9HAD4,Q7Z792, Q8IWG3, Q8IXA9, Q8NDA7, Q9NV62, B4DT55 |
| UniProt Related Accession: | Q9HAD4 |
| Molecular Weight: | 45,506 Da |
| NCBI Full Name: | WD repeat-containing protein 41 |
| NCBI Synonym Full Names: | WD repeat domain 41 |
| NCBI Official Symbol: | WDR41 |
| NCBI Official Synonym Symbols: | MSTP048 |
| NCBI Protein Information: | WD repeat-containing protein 41 |
| UniProt Protein Name: | WD repeat-containing protein 41 |
| UniProt Synonym Protein Names: | |
| Protein Family: | WD repeat-containing protein |
| UniProt Gene Name: | WDR41 |
| UniProt Entry Name: | WDR41_HUMAN |
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