WDR24 Antibody (PACO62775)
- SKU:
- PACO62775
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | WDR24 Antibody (PACO62775) |
| Antibody SKU: | PACO62775 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:200-1:500 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human GATOR complex protein WDR24 protein (1-298AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | IHC image of PACO62775 diluted at 1:200 and staining in paraffin-embedded human ovarian tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
| Background: | As a component of the GATOR subcomplex GATOR2, functions within the amino acid, sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex. It is negatively regulated by the upstream amino acid, sensors SESN2 and CASTOR1. In addition to its role in regulation of the TORC1 complex, promotes the acid, fication of lysosomes and facilitates autophagic flux. |
| Synonyms: | GATOR complex protein WDR24 (WD repeat-containing protein 24), WDR24, C16orf21 |
| UniProt Protein Function: | WDR24: Belongs to the WD repeat WDR24 family. 2 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 16p13.3 |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q96S15 |
| NCBI GenInfo Identifier: | 74762692 |
| NCBI Gene ID: | 84219 |
| NCBI Accession: | Q96S15.1 |
| UniProt Secondary Accession: | Q96S15,Q96GC7, Q9H0B7, A2IDB8, D3DU59 |
| UniProt Related Accession: | Q96S15 |
| Molecular Weight: | 88,207 Da |
| NCBI Full Name: | WD repeat-containing protein 24 |
| NCBI Synonym Full Names: | WD repeat domain 24 |
| NCBI Official Symbol: | WDR24 |
| NCBI Official Synonym Symbols: | JFP7; C16orf21 |
| NCBI Protein Information: | WD repeat-containing protein 24 |
| UniProt Protein Name: | WD repeat-containing protein 24 |
| UniProt Synonym Protein Names: | |
| Protein Family: | WD repeat-containing protein |
| UniProt Gene Name: | WDR24 |
| UniProt Entry Name: | WDR24_HUMAN |
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