WDFY3 Antibody (PACO58260)
- SKU:
- PACO58260
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | WDFY3 Antibody (PACO58260) |
| Antibody SKU: | PACO58260 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human WD repeat and FYVE domain-containing protein 3 protein (1-100AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human gastric cancer using PACO58260 at dilution of 1:100. |
 | Immunofluorescent analysis of Hela cells using PACO58260 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
 | Immunohistochemistry of paraffin-embedded human colon cancer using PACO58260 at dilution of 1:100. |
| Background: | Required for selective autophagy (aggrephagy) but not for autophagic degradation of bulk cytospol in response to starvation. Involved in the formation and degradation of cytoplasmic polyubiquitin-containing bodies (p62 bodies, ALIS/aggresome-like induced structures). May play a role as adaptor or scaffolding protein by promoting the association of the E3-like ligase ATG12-ATG5-ATG16L and LC3 to ubiquitinated target substrate. The association with GABARAP is required for its recruitment to LC3B-positive p62 bodies suggesting a role in targeting certain p62 structures for clearance. Involved in midbody ring degradation. |
| Synonyms: | WD repeat and FYVE domain-containing protein 3 (Autophagy-linked FYVE protein) (Alfy), WDFY3, KIAA0993 |
| UniProt Protein Function: | WDFY3: 2 isoforms of the human protein are produced by alternative splicing.Protein type: Lipid-binding; Nuclear envelope; Membrane protein, peripheral; TransferaseChromosomal Location of Human Ortholog: 4q21.23Cellular Component: PML body; nuclear membrane; extrinsic to membrane; cytoplasm; autophagic vacuole; nuclear envelope; inclusion bodyMolecular Function: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity; protein binding; metal ion binding; phosphatidylinositol bindingBiological Process: endosome transport; positive regulation of macroautophagy |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a phosphatidylinositol 3-phosphate-binding protein that functions as a master conductor for aggregate clearance by autophagy. This protein shuttles from the nuclear membrane to colocalize with aggregated proteins, where it complexes with other autophagic components to achieve macroautophagy-mediated clearance of these aggregated proteins. However, it is not necessary for starvation-induced macroautophagy. [provided by RefSeq, May 2010] |
| UniProt Code: | Q8IZQ1 |
| NCBI GenInfo Identifier: | 156230428 |
| NCBI Gene ID: | 23001 |
| NCBI Accession: | AAI48299.1 |
| UniProt Secondary Accession: | Q8IZQ1,Q4W5K5, Q6P0Q5, Q8N1T2, Q8NAV6, Q96BS7, Q96D33 Q96N85, Q9Y2J7 |
| UniProt Related Accession: | Q8IZQ1 |
| Molecular Weight: | 393,367 Da |
| NCBI Full Name: | WD repeat and FYVE domain containing 3 |
| NCBI Synonym Full Names: | WD repeat and FYVE domain containing 3 |
| NCBI Official Symbol: | WDFY3 |
| NCBI Official Synonym Symbols: | ALFY; ZFYVE25 |
| NCBI Protein Information: | WD repeat and FYVE domain-containing protein 3; autophagy-linked FYVE protein |
| UniProt Protein Name: | WD repeat and FYVE domain-containing protein 3 |
| UniProt Synonym Protein Names: | Autophagy-linked FYVE protein; Alfy |
| Protein Family: | WD repeat and FYVE domain-containing protein |
| UniProt Gene Name: | WDFY3 |
| UniProt Entry Name: | WDFY3_HUMAN |
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