WDFY1 Antibody (PACO49234)
- SKU:
- PACO49234
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | WDFY1 Antibody (PACO49234) |
| Antibody SKU: | PACO49234 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Recombinant Human WD repeat and FYVE domain-containing protein 1 protein (261-357AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: Mouse liver tissue, Mouse kidney tissue. All lanes: WDFY1 antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 47 kDa. Observed band size: 47 kDa.. |
| Background: | Positively regulates TLR3- and TLR4-mediated signaling pathways by bridging the interaction between TLR3 or TLR4 and TICAM1. Promotes TLR3/4 ligand-induced activation of transcription factors IRF3 and NF-kappa-B, as well as the production of IFN-β and inflammatory cytokines. |
| Synonyms: | WD repeat and FYVE domain-containing protein 1 (FENS-1) (Phosphoinositide-binding protein 1) (WD40- and FYVE domain-containing protein 1) (Zinc finger FYVE domain-containing protein 17), WDFY1, KIAA1435 WDF1 ZFYVE17 |
| UniProt Protein Function: | WDFY1: Binds PtdIns3P in vitro with high specificity over other phosphoinositides.Chromosomal Location of Human Ortholog: 2q36.1Cellular Component: cytosol; early endosome; nucleusMolecular Function: phosphatidylinositol binding; protein bindingBiological Process: positive regulation of toll-like receptor 3 signaling pathway; positive regulation of toll-like receptor 4 signaling pathway |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene is a phosphatidylinositol 3-phosphate binding protein, which contains a FYVE zinc finger domain and multiple WD-40 repeat domains. When exogenously expressed, it localizes to early endosomes. Mutagenesis analysis demonstrates that this endosomal localization is mediated by the FYVE domain. [provided by RefSeq, Jan 2015] |
| UniProt Code: | Q8IWB7 |
| NCBI GenInfo Identifier: | 18482373 |
| NCBI Gene ID: | 57590 |
| NCBI Accession: | NP_065881.1 |
| UniProt Secondary Accession: | Q8IWB7,Q53S17, Q9H9D5, Q9P2B3 |
| UniProt Related Accession: | Q8IWB7 |
| Molecular Weight: | |
| NCBI Full Name: | WD repeat and FYVE domain-containing protein 1 |
| NCBI Synonym Full Names: | WD repeat and FYVE domain containing 1 |
| NCBI Official Symbol: | WDFY1 |
| NCBI Official Synonym Symbols: | WDF1; FENS-1; ZFYVE17 |
| NCBI Protein Information: | WD repeat and FYVE domain-containing protein 1 |
| UniProt Protein Name: | WD repeat and FYVE domain-containing protein 1 |
| UniProt Synonym Protein Names: | FENS-1; Phosphoinositide-binding protein 1; WD40- and FYVE domain-containing protein 1; Zinc finger FYVE domain-containing protein 17 |
| Protein Family: | WD repeat and FYVE domain-containing protein |
| UniProt Gene Name: | WDFY1 |
| UniProt Entry Name: | WDFY1_HUMAN |
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