WASHC3 Antibody (PACO42622)
- SKU:
- PACO42622
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | WASHC3 Antibody (PACO42622) |
| Antibody SKU: | PACO42622 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA |
| Recommended Dilutions: | |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human WASH complex subunit 3 protein (1-194AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Background: | Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes seems to inhibit WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization, and which is involved in regulation of the fission of tubules that serve as transport intermediates during endosome sorting. |
| Synonyms: | WASH complex subunit 3 (Coiled-coil domain-containing protein 53), WASHC3 |
| UniProt Protein Function: | CCDC53: Component of the WASH complex, a complex present at the surface of endosomes that recruits and activates the Arp2/3 complex to induce actin polymerization. The WASH complex plays a key role in the fission of tubules that serve as transport intermediates during endosome sorting. Belongs to the CCDC53 family.Chromosomal Location of Human Ortholog: 12q23.2Cellular Component: intracellular membrane-bound organelle; early endosome; actin cytoskeletonMolecular Function: protein bindingBiological Process: protein transport |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q9Y3C0 |
| NCBI GenInfo Identifier: | 7705622 |
| NCBI Gene ID: | 51019 |
| NCBI Accession: | NP_057137.1 |
| UniProt Secondary Accession: | Q9Y3C0,Q53FF0, Q6IAI4, Q96QK0, B2RC74 |
| UniProt Related Accession: | Q9Y3C0 |
| Molecular Weight: | 21,173 Da |
| NCBI Full Name: | WASH complex subunit CCDC53 isoform 1 |
| NCBI Synonym Full Names: | coiled-coil domain containing 53 |
| NCBI Official Symbol: | CCDC53 |
| NCBI Official Synonym Symbols: | CGI-116 |
| NCBI Protein Information: | WASH complex subunit CCDC53; coiled-coil domain-containing protein 53 |
| UniProt Protein Name: | WASH complex subunit CCDC53 |
| UniProt Synonym Protein Names: | Coiled-coil domain-containing protein 53 |
| Protein Family: | WASH complex |
| UniProt Gene Name: | CCDC53 |
| UniProt Entry Name: | CCD53_HUMAN |
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