VWA5A Antibody (PACO15860)
- SKU:
- PACO15860
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | VWA5A Antibody (PACO15860) |
| Antibody SKU: | PACO15860 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:2000, IHC:1:100-1:300 |
| Species Reactivity: | Human |
| Immunogen: | Fusion protein of human VWA5A |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO15860(VWA5A Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: x200). |
 | Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Human Adrenal pheochromocytoma tissue, Jurkat cells, A549 cells, Primary antibody: PACO15860(VWA5A Antibody) at dilution 1/275, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds. |
 | The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO15860(VWA5A Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: x200). |
| Background: | VWA5A (von Willebrand factor A domain containing 5A), also known as BCSC-1 (breast cancer suppressor candidate 1) or LOH11CR2A (loss of heterozygosity 11 chromosomal region 2 gene A protein), is a 786 amino acid, protein containing one VIT domain and one VWFA domain. VWA5A is expressed at low levels in various tissues, with no expression found in 80% of tumor cell lines. Likely acting as a tumor suppressor gene, deletion of VWA5A leads to loss of heterozygosity (LOH) in breast and ovarian tumors, and may have an important role as a potential gene therapy target. Abnormal expression of VWA5A may lead to an increase in adhesion of CNE-2L2 cells associated with an increase in expression of E-cadherin, alpha-catenin, and p53, resulting in a decrease of malignant activity in cells with ectopic expression of VWA5A. |
| Synonyms: | von Willebrand factor A domain containing 5A |
| UniProt Protein Function: | VWA5A: May play a role in tumorigenesis as a tumor suppressor. Altered expression of this protein and disruption of the molecular pathway it is involved in, may contribute directly to or modify tumorigenesis. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Tumor suppressor Chromosomal Location of Human Ortholog: 11q24.1 Cellular Component: nucleoplasm; nucleus |
| UniProt Code: | O00534 |
| NCBI GenInfo Identifier: | 62512155 |
| NCBI Gene ID: | 4013 |
| NCBI Accession: | O00534.2 |
| UniProt Secondary Accession: | O00534,Q6UN19, Q6UN20, Q9BVF8, |
| UniProt Related Accession: | O00534 |
| Molecular Weight: | 29,235 Da |
| NCBI Full Name: | von Willebrand factor A domain-containing protein 5A |
| NCBI Synonym Full Names: | von Willebrand factor A domain containing 5A |
| NCBI Official Symbol: | VWA5A |
| NCBI Official Synonym Symbols: | BCSC1; BCSC-1; LOH11CR2A |
| NCBI Protein Information: | von Willebrand factor A domain-containing protein 5A; breast cancer suppressor candidate 1; loss of heterozygosity 11 chromosomal region 2 gene A protein; loss of heterozygosity, 11, chromosomal region 2, gene A; ortholog of mouse AW551984 |
| UniProt Protein Name: | von Willebrand factor A domain-containing protein 5A |
| UniProt Synonym Protein Names: | Breast cancer suppressor candidate 1; BCSC-1; Loss of heterozygosity 11 chromosomal region 2 gene A protein |
| Protein Family: | von Willebrand factor A domain-containing protein |
| UniProt Gene Name: | VWA5A |
| UniProt Entry Name: | VMA5A_HUMAN |
| Antibodies | ELISA Kits |
| VWA5A Antibody (PACO00464) | LHR2A Colorimetric Cell-Based ELISA |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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