VPS41 Antibody (PACO17435)
- SKU:
- PACO17435
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | VPS41 Antibody (PACO17435) |
| Antibody SKU: | PACO17435 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:25-1:100 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Fusion protein of human VPS41 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO17435(VPS41 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO17435(VPS41 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200). |
| Background: | Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human ortholog of yeast Vps41 protein which is also conserved in Drosophila, tomato, and Arabidopsis. Expression studies in yeast and human indicate that this protein may be involved in the formation and fusion of transport vesicles from the Golgi. Several transcript variants encoding different isoforms have been described for this gene, however, the full-length nature of not all is known. |
| Synonyms: | vacuolar protein sorting 41 homolog (S. cerevisiae) |
| UniProt Protein Function: | VPS41: Required for vacuolar assembly and vacuolar traffic. Belongs to the VPS41 family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Ubiquitin conjugating system; VesicleChromosomal Location of Human Ortholog: 7p14-p13Cellular Component: clathrin-coated vesicle; endosome membrane; late endosome membrane; lysosomal membraneMolecular Function: GTPase binding; identical protein binding; protein bindingBiological Process: endosomal vesicle fusion; endosome to lysosome transport; protein targeting to vacuole; vacuole fusion, non-autophagic |
| UniProt Protein Details: | |
| NCBI Summary: | Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human ortholog of yeast Vps41 protein which is also conserved in Drosophila, tomato, and Arabidopsis. Expression studies in yeast and human indicate that this protein may be involved in the formation and fusion of transport vesicles from the Golgi. Several transcript variants encoding different isoforms have been described for this gene, however, the full-length nature of not all is known. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P49754 |
| NCBI GenInfo Identifier: | 28278744 |
| NCBI Gene ID: | 27072 |
| NCBI Accession: | BC044851 |
| UniProt Secondary Accession: | P49754,Q86TP8, Q99851, Q99852, E9PF36 |
| UniProt Related Accession: | P49754 |
| Molecular Weight: | 95,924 Da |
| NCBI Full Name: | Homo sapiens vacuolar protein sorting 41 homolog (S. cerevisiae), mRNA |
| NCBI Synonym Full Names: | VPS41, HOPS complex subunit |
| NCBI Official Symbol: | VPS41 |
| NCBI Official Synonym Symbols: | HVPS41; HVSP41; hVps41p |
| NCBI Protein Information: | vacuolar protein sorting-associated protein 41 homolog |
| UniProt Protein Name: | Vacuolar protein sorting-associated protein 41 homolog |
| UniProt Synonym Protein Names: | S53 |
| Protein Family: | Vacuolar protein sorting-associated protein |
| UniProt Gene Name: | VPS41 |
| UniProt Entry Name: | VPS41_HUMAN |
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