Antibody Name:	VPS26A Antibody (PACO20865)
Antibody SKU:	PACO20865
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, WB, IHC
Recommended Dilutions:	ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:25-1:100
Species Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide of human VPS26A

Form:	Liquid
Storage Buffer:	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:	Antigen affinity purification
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using PACO20865(VPS26A Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200).
	Gel: 12%SDS-PAGE,Lysate: 40 µg,Lane 1-7: Human placenta tissue, PC3 cells, Human fetal liver tissue, HepG2 cells, Hela cells, A431 cells, 293T cells,Primary antibody: PACO20865(VPS26A Antibody) at dilution 1/200 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 40 seconds.
	The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO20865(VPS26A Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200).

Background:

This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. Alternative splicing results in multiple transcript variants encoding different isoforms.

Synonyms:

vacuolar protein sorting 26 homolog A (S. pombe)

UniProt Protein Function:	VPS26A: Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Belongs to the VPS26 family.
UniProt Protein Details:	Protein type:Vesicle Chromosomal Location of Human Ortholog: 10q21.1 Cellular Component: cytosol; early endosome; endosome; endosome membrane; intracellular membrane-bound organelle; retromer complex; vesicle Molecular Function:protein binding; protein transporter activity Biological Process: intracellular protein transport; regulation of macroautophagy; retrograde transport, endosome to Golgi; Wnt receptor signaling pathway
NCBI Summary:	This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
UniProt Code:	O75436
NCBI GenInfo Identifier:	25453454
NCBI Gene ID:	9559
NCBI Accession:	O75436.2
UniProt Secondary Accession:	O75436,Q8TBH4, Q9H982, A8MZ56, B2RDD3,
UniProt Related Accession:	O75436
Molecular Weight:	28,938 Da
NCBI Full Name:	Vacuolar protein sorting-associated protein 26A
NCBI Synonym Full Names:	VPS26, retromer complex component A
NCBI Official Symbol:	VPS26A
NCBI Official Synonym Symbols:	HB58; PEP8A; VPS26; Hbeta58
NCBI Protein Information:	vacuolar protein sorting-associated protein 26A
UniProt Protein Name:	Vacuolar protein sorting-associated protein 26A
UniProt Synonym Protein Names:	Vesicle protein sorting 26A; hVPS26
Protein Family:	Vacuolar protein sorting-associated protein
UniProt Gene Name:	VPS26A
UniProt Entry Name:	VP26A_HUMAN