Antibody Name:	VPS26A Antibody (PACO20864)
Antibody SKU:	PACO20864
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, WB, IHC
Recommended Dilutions:	ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:30-1:150
Species Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide of human VPS26A

Form:	Liquid
Storage Buffer:	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:	Antigen affinity purification
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO20864(VPS26A Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
	Gel: 12%SDS-PAGE,Lysate: 40 µg,Lane 1-7: 293T cells, A431 cells, Hela cells, HepG2 cells, Human fetal liver tissue, PC3 cells, Human placenta tissue,Primary antibody: PACO20864(VPS26A Antibody) at dilution 1/200 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 40 seconds.
	The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20864(VPS26A Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).

Background:

This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. Alternative splicing results in multiple transcript variants encoding different isoforms.

Synonyms:

vacuolar protein sorting 26 homolog A (S. pombe)

UniProt Protein Function:	VPS26A: Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Belongs to the VPS26 family.
UniProt Protein Details:	Protein type:Vesicle Chromosomal Location of Human Ortholog: 10q21.1 Cellular Component: cytosol; early endosome; endosome; endosome membrane; intracellular membrane-bound organelle; retromer complex; vesicle Molecular Function:protein binding; protein transporter activity Biological Process: intracellular protein transport; regulation of macroautophagy; retrograde transport, endosome to Golgi; Wnt receptor signaling pathway
NCBI Summary:	This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
UniProt Code:	O75436
NCBI GenInfo Identifier:	25453454
NCBI Gene ID:	9559
NCBI Accession:	O75436.2
UniProt Secondary Accession:	O75436,Q8TBH4, Q9H982, A8MZ56, B2RDD3,
UniProt Related Accession:	O75436
Molecular Weight:	28,938 Da
NCBI Full Name:	Vacuolar protein sorting-associated protein 26A
NCBI Synonym Full Names:	VPS26, retromer complex component A
NCBI Official Symbol:	VPS26A
NCBI Official Synonym Symbols:	HB58; PEP8A; VPS26; Hbeta58
NCBI Protein Information:	vacuolar protein sorting-associated protein 26A
UniProt Protein Name:	Vacuolar protein sorting-associated protein 26A
UniProt Synonym Protein Names:	Vesicle protein sorting 26A; hVPS26
Protein Family:	Vacuolar protein sorting-associated protein
UniProt Gene Name:	VPS26A
UniProt Entry Name:	VP26A_HUMAN