VP35 Antibody (PACO40042)
- SKU:
- PACO40042
- Product Type:
- Antibody
- Reactivity:
- Virus
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | VP35 Antibody (PACO40042) |
| Antibody SKU: | PACO40042 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA |
| Recommended Dilutions: | |
| Species Reactivity: | Reston ebolavirus |
| Immunogen: | Recombinant Reston ebolavirus Polymerase cofactor VP35 protein (1-329AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Background: | Acts as a polymerase cofactor in the RNA polymerase transcription and replication complex. Prevents establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of interferon regulatory factor 3 (IRF3), a transcription factor critical for the induction of interferons α and beta. This blockage is produced through the interaction with and inhibition host IKBKE and TBK1 producing a strong inhibition of the phosphorylation and activation of IRF3. Also inhibits the antiviral effect mediated by the interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2/PKR. |
| Synonyms: | Polymerase cofactor VP35, VP35 |
| UniProt Protein Function: | Acts as a polymerase cofactor in the RNA polymerase transcription and replication complex. Prevents establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of interferon regulatory factor 3 (IRF3), a transcription factor critical for the induction of interferons alpha and beta. This blockage is produced through the interaction with and inhibition host IKBKE and TBK1 producing a strong inhibition of the phosphorylation and activation of IRF3. Also inhibits the antiviral effect mediated by the interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2/PKR (). |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q91DE0 |
| NCBI GenInfo Identifier: | 81961765 |
| NCBI Gene ID: | |
| NCBI Accession: | Q91DE0.1 |
| UniProt Secondary Accession: | Q91DE0 |
| UniProt Related Accession: | Q91DE0 |
| Molecular Weight: | 36,386 Da |
| NCBI Full Name: | Polymerase cofactor VP35 |
| NCBI Synonym Full Names: | |
| NCBI Official Symbol: | |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | |
| UniProt Protein Name: | Polymerase cofactor VP35 |
| UniProt Synonym Protein Names: | |
| Protein Family: | Polymerase cofactor |
| UniProt Gene Name: | VP35 |
| UniProt Entry Name: |
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