Antibody Name:	VLDLR Antibody (PACO20858)
Antibody SKU:	PACO20858
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, IHC
Recommended Dilutions:	ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide of human VLDLR

Form:	Liquid
Storage Buffer:	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:	Antigen affinity purification
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO20858(VLDLR Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200).
	The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20858(VLDLR Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200).

Background:

The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. This gene encodes a lipoprotein receptor that is a member of the LDLR family and plays important roles in VLDL-triglyceride metabolism and the reelin signaling pathway. Mutations in this gene cause VLDLR-associated cerebellar hypoplasia. Alternative splicing generates multiple transcript variants encoding distinct isoforms for this gene.

Synonyms:

very low density lipoprotein receptor

UniProt Protein Function:	VLDLR: Binds VLDL and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Binding to Reelin induces tyrosine phosphorylation of Dab1 and modulation of Tau phosphorylation. Defects in VLDLR are the cause of cerebellar ataxia mental retardation and dysequilibrium syndrome type 1 (CMARQ1); also known as dysequilibrium syndrome (DES) or non- progressive cerebellar disorder with mental retardation. CMARQ1 is a congenital, non-progressive cerebellar ataxia associated with disturbed equilibrium, delayed ambulation, mental retardation and cerebellar hypoplasia. Additional features include short stature, strabismus, pes planus and, rarely, seizures. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 9p24 Cellular Component: membrane; plasma membrane; integral to membrane; coated pit; receptor complex Molecular Function:very-low-density lipoprotein receptor activity; low-density lipoprotein receptor activity; very-low-density lipoprotein binding; protein binding; apolipoprotein binding; calcium ion binding; glycoprotein binding; calcium-dependent protein binding Biological Process: nervous system development; receptor-mediated endocytosis; cholesterol metabolic process; positive regulation of protein kinase activity; ventral spinal cord development; negative regulation of transcription from RNA polymerase II promoter; signal transduction; lipid transport; memory Disease: Cerebellar Ataxia, Mental Retardation, And Dysequilibrium Syndrome 1
NCBI Summary:	The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. This gene encodes a lipoprotein receptor that is a member of the LDLR family and plays important roles in VLDL-triglyceride metabolism and the reelin signaling pathway. Mutations in this gene cause VLDLR-associated cerebellar hypoplasia. Alternative splicing generates multiple transcript variants encoding distinct isoforms for this gene. [provided by RefSeq, Aug 2009]
UniProt Code:	P98155
NCBI GenInfo Identifier:	65301167
NCBI Gene ID:	7436
NCBI Accession:	NP_003374.3
UniProt Secondary Accession:	P98155,Q5VVF6, B2RMZ7, D3DRH6,
UniProt Related Accession:	P98155
Molecular Weight:	96,098 Da
NCBI Full Name:	very low-density lipoprotein receptor isoform a
NCBI Synonym Full Names:	very low density lipoprotein receptor
NCBI Official Symbol:	VLDLR
NCBI Official Synonym Symbols:	CARMQ1; CHRMQ1; VLDLRCH
NCBI Protein Information:	very low-density lipoprotein receptor; VLDL-R; VLDL receptor
UniProt Protein Name:	Very low-density lipoprotein receptor
Protein Family:	Very low-density lipoprotein receptor
UniProt Gene Name:	VLDLR
UniProt Entry Name:	VLDLR_HUMAN

Antibodies	ELISA Kits
Anti-VLDLR Antibody (CAB7345)	Human VLDL R / Very low-density lipoprotein receptor ELISA Kit
	Human VLDL / Very low-density lipoprotein ELISA Kit
	Human Very low-density lipoprotein receptor (VLDLR) ELISA Kit

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)