| UniProt Protein Function: | VIPR1: This is a receptor for VIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The affinity is VIP = PACAP-27 > PACAP-38. Belongs to the G-protein coupled receptor 2 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Motility/polarity/chemotaxis; Membrane protein, multi-pass; GPCR, family 2; Receptor, GPCR Chromosomal Location of Human Ortholog: 3p22 Cellular Component: integral to plasma membrane; plasma membrane; receptor complex Molecular Function:vasoactive intestinal polypeptide receptor activity; protein binding Biological Process: synaptic transmission; G-protein signaling, coupled to cyclic nucleotide second messenger; G-protein coupled receptor protein signaling pathway; muscle contraction; digestion; positive regulation of cell proliferation; immune response |
| NCBI Summary: | This gene encodes a receptor for vasoactive intestinal peptide, a small neuropeptide. Vasoactive intestinal peptide is involved in smooth muscle relaxation, exocrine and endocrine secretion, and water and ion flux in lung and intestinal epithelia. Its actions are effected through integral membrane receptors associated with a guanine nucleotide binding protein which activates adenylate cyclase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] |
| UniProt Code: | P32241 |
| NCBI GenInfo Identifier: | 418253 |
| NCBI Gene ID: | 7433 |
| NCBI Accession: | P32241.1 |
| UniProt Secondary Accession: | P32241,Q15871, Q6P2M6, A5JUT9, B3KPV1, B4DEB5, B4DGI4 F5H1F5, G3V0I1, |
| UniProt Related Accession: | P32241 |
| Molecular Weight: | 47,201 Da |
| NCBI Full Name: | Vasoactive intestinal polypeptide receptor 1 |
| NCBI Synonym Full Names: | vasoactive intestinal peptide receptor 1 |
| NCBI Official Symbol: | VIPR1 |
| NCBI Official Synonym Symbols: | II; HVR1; RDC1; V1RG; VIPR; VIRG; VAPC1; VPAC1; VPAC1R; VIP-R-1; VPCAP1R; PACAP-R2; PACAP-R-2 |
| NCBI Protein Information: | vasoactive intestinal polypeptide receptor 1; VIP receptor, type I; PACAP type II receptor; VIP and PACAP receptor 1; pituitary adenylate cyclase activating polypeptide receptor, type II |
| UniProt Protein Name: | Vasoactive intestinal polypeptide receptor 1 |
| UniProt Synonym Protein Names: | Pituitary adenylate cyclase-activating polypeptide type II receptor; PACAP type II receptor; PACAP-R-2; PACAP-R2; VPAC1 |
| Protein Family: | Vasoactive intestinal polypeptide receptor |
| UniProt Gene Name: | VIPR1 |
| UniProt Entry Name: | VIPR1_HUMAN |
