Vimentin Monoclonal Antibody, Biotin [hVimentin] (CPAB0496)

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SKU:
CPAB0496
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Universal
Host Species:
Mouse
Isotype:
IgG1
Clone:
hVimentin
Applications:
IHC

Description

system_update_alt Datasheet
Product Name:Vimentin Antibody, Biotin
Product Sku:CPAB0496
Size:500μg
Host Species:mouse
Immunogen:Purified Human Vimentin.
Clone:hVimentin.
Reactivity:Other bodies
Applications:Immunohistochemistry
Purification Method:Ion exchange column.
Isotype:IgG1
Background:Vimentin expression in human malignant glioma cells depends on cellular density, algorithms of drug delivery and chemo/radio treatment. Vimentin and detyrosinated microtubules provide structural support for the extensive microtentacles observed in detached tumor cells and a mechanism to promote successful metastatic spread. Primary colorectal carcinomas display aberrant expression of vimentin, and have activated Notch and TGFbeta signaling pathways. Vimentin is a strong arterial substrate for transglutaminases. Transglutaminase-mediated vimentin dimerization results in a novel unifying pathway by which vasodilatory and remodeling responses may be regulated. Ablation of vimentin expression inhibits migration and invasion of colon and breast cancer cell lines.
Synonyms:
Storage Buffer:In lyophilized form, for long periods, store at 4°C in a dry environment. After reconstitution, if not intended for use within a month, aliquot and store at -20°C.
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