VHLL Antibody (PACO37082)
- SKU:
- PACO37082
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | VHLL Antibody (PACO37082) |
| Antibody SKU: | PACO37082 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human von Hippel-Lindau-like protein (1-139AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human placenta tissue using PACO37082 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human endometrial cancer using PACO37082 at dilution of 1:100. |
| Background: | Functions as a dominant-negative VHL to serve as a protector of HIFalpha. |
| Synonyms: | von Hippel-Lindau-like protein (VHL-like protein) (VLP), VHLL, VLP |
| UniProt Protein Function: | Functions as a dominant-negative VHL to serve as a protector of HIFalpha. |
| UniProt Protein Details: | |
| NCBI Summary: | Von Hippel-Lindau (VHL) tumor suppressor protein is a component of an E3 ubiquitin ligase complex that selectively ubiquitinates the alpha subunit of the hypoxia-inducible factor (HIF) transcription factor for proteasome-mediated degradation. Inactivation of VHL causes VHL disease and sporadic kidney cancer. This gene encodes a VHL homolog that lacks one of two key domains necessary for VHL function. This gene may contribute to the regulation of oxygen homeostasis and neovascularization during placenta development. This gene is intronless, and can also be interpreted as a retrotransposed pseudogene of the VHL locus located on chromosome 3. However, the protein is represented in this RefSeq due to evidence in PMID:14757845 that strongly suggests it is translated. The same publication also indicates that this protein binds HIF alpha but fails to recruit the E3 ubiquitin ligase complex, and it therefore functions as a dominant-negative VHL protein and a protector of HIF alpha. [provided by RefSeq, Jan 2010] |
| UniProt Code: | Q6RSH7 |
| NCBI GenInfo Identifier: | 51972218 |
| NCBI Gene ID: | 391104 |
| NCBI Accession: | NP_001004319.1 |
| UniProt Secondary Accession: | Q6RSH7,A1L4M4 |
| UniProt Related Accession: | Q6RSH7 |
| Molecular Weight: | 15,781 Da |
| NCBI Full Name: | von Hippel-Lindau-like protein |
| NCBI Synonym Full Names: | VHL like |
| NCBI Official Symbol: | VHLL |
| NCBI Official Synonym Symbols: | VLP; VHLP |
| NCBI Protein Information: | von Hippel-Lindau-like protein |
| UniProt Protein Name: | von Hippel-Lindau-like protein |
| UniProt Synonym Protein Names: | |
| Protein Family: | Von Hippel-Lindau-like protein |
| UniProt Gene Name: | VHLL |
| UniProt Entry Name: |
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